عنوان

Anaerobiosis and stemness :

شابک

0128005408

شابک

9780128005408

شابک اشتباه

9780128006115

شماره

dltt

عنوان اصلي

Anaerobiosis and stemness :

نام عام مواد

[Book]

ساير اطلاعات عنواني

an evolutionary paradigm /

نام نخستين پديدآور

Zoran Ivanovic, Marija Vlaski-Lafarge

نام خاص و کميت اثر

viii, 312 pages :

ساير جزييات

color illustrations ;

ابعاد

24 cm

متن يادداشت

Includes bibliographical references and index

متن يادداشت

Introduction : special remarks -- What entity could be called a stem cell? -- In situ Normoxia versus "hypoxia" -- Part 1. Anaerobiosis and stem cell entity. The "hypoxic" stem cell niche -- Low O2 concentrations and the maintenance of stem cells ex vivo -- Quiescence/proliferation issue and stem cell niche -- Metabolic peculiarities of the stem cell entity : energetic metabolism and oxidative status -- Molecular basis of "hypoxic" signaling, quiescence, self-renewal, and differentiation in stem cells -- Part 2. Anaerobic-to-aerobic eukaryote evolution : a paradigm for stem cell self-renewal, commitment and differentiation?. Evolution of eukaryotes with respect to atmosphere oxygen appearance and rise : anaerobiosis, facultative aerobiosis, and aerobiosis -- Evolution of mitochondria in eukaryotes versus mitochondria "maturing" from the stage of stem cells to committed progenitors and mature cells -- Evolutionary origins of stemness : relationship between self-renewal and ancestral eukaryote biology; conservation of self-renewal principle in parallel with adaptation to O2 -- Metabolic and genetic features of ancestral eukaryotes versus metabolism and "master pluripotency genes" of stem cells -- Other features concerning the analogy "stem cells: primitive eukaryotes" : ABC transporters' anaerobiosis/stemness link -- Harnessing anaerobic nature of stem cells for use in regenerative medicine -- Cancer stem cell case and evolutionary paradigm

بدون عنوان

0

متن يادداشت

"Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation. This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation, as well as cell engineering and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell and developmental biologists alike, as well as oncologists, cancer biologists, and researchers using stem cells for regeneration."--Page 4 of cover

موضوع مستند نشده

Anaerobiosis-- Research

موضوع مستند نشده

Anaerobiosis-- Therapeutic use

موضوع مستند نشده

Stem cells-- Research

موضوع مستند نشده

Stem cells-- Therapeutic use

موضوع مستند نشده

Stem Cells

شماره

ويراست

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Ivanovic, Zoran

مستند نام اشخاص تاييد نشده

Vlaski-Lafarge, Marija

تاريخ عمليات

20160304123534.0

قواعد فهرست نويسي ( بخش توصيفي )

rda

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y