عنوان

Anaerobiosis and stemness :

0128005408

9780128005408

9780128006115

dltt

Anaerobiosis and stemness :

[Book]

an evolutionary paradigm /

Zoran Ivanovic, Marija Vlaski-Lafarge

viii, 312 pages :

color illustrations ;

24 cm

Includes bibliographical references and index

Introduction : special remarks -- What entity could be called a stem cell? -- In situ Normoxia versus "hypoxia" -- Part 1. Anaerobiosis and stem cell entity. The "hypoxic" stem cell niche -- Low O2 concentrations and the maintenance of stem cells ex vivo -- Quiescence/proliferation issue and stem cell niche -- Metabolic peculiarities of the stem cell entity : energetic metabolism and oxidative status -- Molecular basis of "hypoxic" signaling, quiescence, self-renewal, and differentiation in stem cells -- Part 2. Anaerobic-to-aerobic eukaryote evolution : a paradigm for stem cell self-renewal, commitment and differentiation?. Evolution of eukaryotes with respect to atmosphere oxygen appearance and rise : anaerobiosis, facultative aerobiosis, and aerobiosis -- Evolution of mitochondria in eukaryotes versus mitochondria "maturing" from the stage of stem cells to committed progenitors and mature cells -- Evolutionary origins of stemness : relationship between self-renewal and ancestral eukaryote biology; conservation of self-renewal principle in parallel with adaptation to O2 -- Metabolic and genetic features of ancestral eukaryotes versus metabolism and "master pluripotency genes" of stem cells -- Other features concerning the analogy "stem cells: primitive eukaryotes" : ABC transporters' anaerobiosis/stemness link -- Harnessing anaerobic nature of stem cells for use in regenerative medicine -- Cancer stem cell case and evolutionary paradigm

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"Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation. This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation, as well as cell engineering and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell and developmental biologists alike, as well as oncologists, cancer biologists, and researchers using stem cells for regeneration."--Page 4 of cover

Anaerobiosis-- Research

Anaerobiosis-- Therapeutic use

Stem cells-- Research

Stem cells-- Therapeutic use

Stem Cells

Ivanovic, Zoran

Vlaski-Lafarge, Marija

20160304123534.0

rda

[Book]

Y