عنوان

Anaerobiosis and stemness :

(Number (ISBN

0128005408

(Number (ISBN

9780128005408

Erroneous ISBN

9780128006115

Number

dltt

Title Proper

Anaerobiosis and stemness :

General Material Designation

[Book]

Other Title Information

an evolutionary paradigm /

First Statement of Responsibility

Zoran Ivanovic, Marija Vlaski-Lafarge

Specific Material Designation and Extent of Item

viii, 312 pages :

Other Physical Details

color illustrations ;

Dimensions

24 cm

Text of Note

Includes bibliographical references and index

Text of Note

Introduction : special remarks -- What entity could be called a stem cell? -- In situ Normoxia versus "hypoxia" -- Part 1. Anaerobiosis and stem cell entity. The "hypoxic" stem cell niche -- Low O2 concentrations and the maintenance of stem cells ex vivo -- Quiescence/proliferation issue and stem cell niche -- Metabolic peculiarities of the stem cell entity : energetic metabolism and oxidative status -- Molecular basis of "hypoxic" signaling, quiescence, self-renewal, and differentiation in stem cells -- Part 2. Anaerobic-to-aerobic eukaryote evolution : a paradigm for stem cell self-renewal, commitment and differentiation?. Evolution of eukaryotes with respect to atmosphere oxygen appearance and rise : anaerobiosis, facultative aerobiosis, and aerobiosis -- Evolution of mitochondria in eukaryotes versus mitochondria "maturing" from the stage of stem cells to committed progenitors and mature cells -- Evolutionary origins of stemness : relationship between self-renewal and ancestral eukaryote biology; conservation of self-renewal principle in parallel with adaptation to O2 -- Metabolic and genetic features of ancestral eukaryotes versus metabolism and "master pluripotency genes" of stem cells -- Other features concerning the analogy "stem cells: primitive eukaryotes" : ABC transporters' anaerobiosis/stemness link -- Harnessing anaerobic nature of stem cells for use in regenerative medicine -- Cancer stem cell case and evolutionary paradigm

0

Text of Note

"Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation. This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation, as well as cell engineering and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell and developmental biologists alike, as well as oncologists, cancer biologists, and researchers using stem cells for regeneration."--Page 4 of cover

Anaerobiosis-- Research

Anaerobiosis-- Therapeutic use

Stem cells-- Research

Stem cells-- Therapeutic use

Stem Cells

Number

Edition

Class number

Book number

Ivanovic, Zoran

Vlaski-Lafarge, Marija

Date of Transaction

20160304123534.0

Cataloguing Rules (Descriptive Conventions))

rda

Electronic name

[Book]

Y