عنوان

The cellular response to the genotoxic insult :

شابک

1849731772

شابک

1849732922

شابک

9781849731775

شابک

9781849732925

شماره

b587572

عنوان اصلي

The cellular response to the genotoxic insult :

نام عام مواد

[Book]

ساير اطلاعات عنواني

the question of threshold for genotoxic carcinogens

نام نخستين پديدآور

ed. by Helmut Greim ...

محل نشرو پخش و غیره

Cambridge RSC Publishing

تاریخ نشرو بخش و غیره

2012

عنوان فروست

Issues in toxicology, 13

متن يادداشت

Parallel als Buch-Ausg. erschienen

متن يادداشت

Introduction: The rationale for thresholds for genotoxic carcinogens; Part 1. Threshold effects observed in experimental studies: Mechanisms responsible for the chromosome and gene mutations driving carcinogenesis: implications for dose-response characteristics of mutagenic carcinogens; Dose-effect relationships of DANN-reactive liver carcinogens; DNA alkylation and repair after EEMS exposure: Where do the thresholds for mutagenic/clastogenic effects arise? Part 2. Metabolic inactivation of genotoxic reactants: Enzymatic detoxification of endogenously produced mutagenic carcinogens maintaining cellular homeostasis; Phase 2 detoxifying enzymes and anti-oxygen defense mechanisms in the inactivation of genotoxic carcinogens; Part 3. DNA repair: Consequences and Repair of oxidative DNA damage; The plasticity of DNA damage response during cell differentiation: pathways and consequences; Tumor suppressor protein-mediated regulation of base excision repair in response to DNA damage; Part 4. Apoptosis: Survival and death strategies in cells exposed to genotoxin; Different modes of cell death induced by DNA damage; Transcriptional inhibition by DNA damage as a trigger of cell death; Part 5. Epigenetic mechanisms: The interplay between epigenetics and Gap junctionional intercellular communication; Index

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

ed. by Helmut Greim ...

مستند نام اشخاص تاييد نشده

Helmut Greim

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y