عنوان

The cellular response to the genotoxic insult :

(Number (ISBN

1849731772

(Number (ISBN

1849732922

(Number (ISBN

9781849731775

(Number (ISBN

9781849732925

Number

b587572

Title Proper

The cellular response to the genotoxic insult :

General Material Designation

[Book]

Other Title Information

the question of threshold for genotoxic carcinogens

First Statement of Responsibility

ed. by Helmut Greim ...

Place of Publication, Distribution, etc.

Cambridge RSC Publishing

Date of Publication, Distribution, etc.

2012

Series Title

Issues in toxicology, 13

Text of Note

Parallel als Buch-Ausg. erschienen

Text of Note

Introduction: The rationale for thresholds for genotoxic carcinogens; Part 1. Threshold effects observed in experimental studies: Mechanisms responsible for the chromosome and gene mutations driving carcinogenesis: implications for dose-response characteristics of mutagenic carcinogens; Dose-effect relationships of DANN-reactive liver carcinogens; DNA alkylation and repair after EEMS exposure: Where do the thresholds for mutagenic/clastogenic effects arise? Part 2. Metabolic inactivation of genotoxic reactants: Enzymatic detoxification of endogenously produced mutagenic carcinogens maintaining cellular homeostasis; Phase 2 detoxifying enzymes and anti-oxygen defense mechanisms in the inactivation of genotoxic carcinogens; Part 3. DNA repair: Consequences and Repair of oxidative DNA damage; The plasticity of DNA damage response during cell differentiation: pathways and consequences; Tumor suppressor protein-mediated regulation of base excision repair in response to DNA damage; Part 4. Apoptosis: Survival and death strategies in cells exposed to genotoxin; Different modes of cell death induced by DNA damage; Transcriptional inhibition by DNA damage as a trigger of cell death; Part 5. Epigenetic mechanisms: The interplay between epigenetics and Gap junctionional intercellular communication; Index

Class number

Book number

ed. by Helmut Greim ...

Helmut Greim

Electronic name

[Book]

Y