عنوان

New horizons in predictive drug metabolism and pharmacokinetics

شابک

1782622373

شابک

9781782622376

شماره

b584998

عنوان اصلي

New horizons in predictive drug metabolism and pharmacokinetics

نام عام مواد

[Book]

نام نخستين پديدآور

edited by Alan G.E. Wilson.

محل نشرو پخش و غیره

Cambridge, UK

نام ناشر، پخش کننده و غيره

Royal Society of Chemistry, [

تاریخ نشرو بخش و غیره

2016]

نام خاص و کميت اثر

(xxi, 422 pages .).

عنوان فروست

RSC drug discovery series.

متن يادداشت

How physicochemical properties of drugs affect their metabolism and clearance; Role of solubility, permeability and adsorption in drug discovery in development; Models for nonspecific binding and partitioning; Cytochrome P450 mediated drug metabolism; Non-cytochrome P450 enzymes and glucuronidation; Metabolite profiling; Application of humanised and other transgenic models to predict human responses to drugs; Stem cells and drug metabolism; Chemically reactive versus stable drug metabolites: Role in adverse drug reactions; Integrating metabolism and toxicity properties; Metabolomics-based approaches to determine drug metabolite profiles; Drug-drug ineteractions: regulatory and theoretical considerations, and an industrial perspective; Drug-drug interactions: Computational approaches; Induction of hepatic cytochrome P450 enzymes: Importance in drug development and toxicity; Current status and implications of transporters: QSAR analysis method to evaluate drug-drug interactions of human bile salt export pump (ABCB11/BSEP) and prediction of intrahepatic cholestasis risk; Formulation of optimizing bioavailability; Systems pharmacology modelling; Pharmacokinetic-pharmacodynamic modelling in drug development with special reference to oncology;

موضوع مستند نشده

Drug development.

موضوع مستند نشده

Drugs -- Metabolism.

موضوع مستند نشده

Pharmacokinetics.

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

edited by Alan G.E. Wilson.

مستند نام اشخاص تاييد نشده

A G E Wilson

مستند نام اشخاص تاييد نشده

Royal Society of Chemistry (Great Britain)

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y