عنوان

New horizons in predictive drug metabolism and pharmacokinetics

(Number (ISBN

1782622373

(Number (ISBN

9781782622376

Number

b584998

Title Proper

New horizons in predictive drug metabolism and pharmacokinetics

General Material Designation

[Book]

First Statement of Responsibility

edited by Alan G.E. Wilson.

Place of Publication, Distribution, etc.

Cambridge, UK

Name of Publisher, Distributor, etc.

Royal Society of Chemistry, [

Date of Publication, Distribution, etc.

2016]

Specific Material Designation and Extent of Item

(xxi, 422 pages .).

Series Title

RSC drug discovery series.

Text of Note

How physicochemical properties of drugs affect their metabolism and clearance; Role of solubility, permeability and adsorption in drug discovery in development; Models for nonspecific binding and partitioning; Cytochrome P450 mediated drug metabolism; Non-cytochrome P450 enzymes and glucuronidation; Metabolite profiling; Application of humanised and other transgenic models to predict human responses to drugs; Stem cells and drug metabolism; Chemically reactive versus stable drug metabolites: Role in adverse drug reactions; Integrating metabolism and toxicity properties; Metabolomics-based approaches to determine drug metabolite profiles; Drug-drug ineteractions: regulatory and theoretical considerations, and an industrial perspective; Drug-drug interactions: Computational approaches; Induction of hepatic cytochrome P450 enzymes: Importance in drug development and toxicity; Current status and implications of transporters: QSAR analysis method to evaluate drug-drug interactions of human bile salt export pump (ABCB11/BSEP) and prediction of intrahepatic cholestasis risk; Formulation of optimizing bioavailability; Systems pharmacology modelling; Pharmacokinetic-pharmacodynamic modelling in drug development with special reference to oncology;

Drug development.

Drugs -- Metabolism.

Pharmacokinetics.

Class number

Book number

edited by Alan G.E. Wilson.

A G E Wilson

Royal Society of Chemistry (Great Britain)

Electronic name

[Book]

Y