عنوان

Conjugation--Deconjugation Reactions in Drug Metabolism and Toxicity

شابک

3642784291

شابک

9783642784293

شماره

b543088

عنوان اصلي

Conjugation--Deconjugation Reactions in Drug Metabolism and Toxicity

نام عام مواد

[Book]

نام نخستين پديدآور

edited by Frederick C. Kauffman.

محل نشرو پخش و غیره

Berlin, Heidelberg

نام ناشر، پخش کننده و غيره

Springer Berlin Heidelberg

تاریخ نشرو بخش و غیره

1994

نام خاص و کميت اثر

(XXIV, 530 pages).

عنوان فروست

Handbook of experimental pharmacology, 112.

متن يادداشت

Section I: Transferases and Hydrolases Involved in Phase II Conjugation--Deconjugation Reactions, Genetic Polymorphism and Regulation of Expression --;1 The Uridine Diphosphate Glueuronosyltransferase Multigene Family: Function and Regulation With 7 Figures --;2 Sulfotransferase Enzymes With 6 Figures --;3 Regulation of Expression of Rat Liver Glutathione S-Transferases: Xenobiotic and Antioxidant Induction of the Ya Subunit Gene With 6 Figures --;4 Human N-Acetyltransferases With 3 Figures --;5 Genetic Regulation of the Subcellular Localization and Expression of Glucuronidase With 5 Figures --;6 Microsomal Amidases and Carboxylesterases With 5 Figures --;7 O-, N, and S-Methyltransferases With 2 Figures --;Section II: Regulation of Phase II Conjugation: Deconjugation Reactions in Intact Cells and Tissues --;8 Cofactor Supply as a Rate-Limiting Determinant of Hepatic Conjugation Reactions With 5 Figures --;9 Regulation of Drug Conjugate Production by Futile Cycling in Intact Cells With 4 Figures --;10 Pharmacokinetic Modeling of Drug Conjugates With 22 Figures --;11 Regulation of Drug Conjugate Processing by Hepatocellular Transport Systems With 1 Figure --;Section III: Pharmacology and Toxicology of Drug Conjugates --;12 Biologically Active Conjugates of Drugs and Toxic Chemicals With 5 Figures --;13 Acyl Glucuronides as Chemically Reactive Intermediates With 10 Figures --;14 Roles of Uridine Diphosphate Glucuronosyltransferases in Chemical Carcinogenesis With 9 Figures --;15 Sulfonation in Chemical Carcinogenesis With 11 Figures --;16 Glutathione Conjugate-Mediated Toxicities With 8 Figures --;17 Challenges and Directions for Future Research.

متن يادداشت

In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology.

عنوان اصلي به زبان ديگر

ConjugationDeconjugation Reactions in Drug Metabolism and Toxicity;Handbook of Experimental Pharmacology, vol. 112

موضوع مستند نشده

Medicine.

موضوع مستند نشده

Nuclear medicine.

موضوع مستند نشده

Toxicology.

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

edited by Frederick C. Kauffman.

مستند نام اشخاص تاييد نشده

Frederick C Kauffman

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y