عنوان

Conjugation--Deconjugation Reactions in Drug Metabolism and Toxicity

(Number (ISBN

3642784291

(Number (ISBN

9783642784293

Number

b543088

Title Proper

Conjugation--Deconjugation Reactions in Drug Metabolism and Toxicity

General Material Designation

[Book]

First Statement of Responsibility

edited by Frederick C. Kauffman.

Place of Publication, Distribution, etc.

Berlin, Heidelberg

Name of Publisher, Distributor, etc.

Springer Berlin Heidelberg

Date of Publication, Distribution, etc.

1994

Specific Material Designation and Extent of Item

(XXIV, 530 pages).

Series Title

Handbook of experimental pharmacology, 112.

Text of Note

Section I: Transferases and Hydrolases Involved in Phase II Conjugation--Deconjugation Reactions, Genetic Polymorphism and Regulation of Expression --;1 The Uridine Diphosphate Glueuronosyltransferase Multigene Family: Function and Regulation With 7 Figures --;2 Sulfotransferase Enzymes With 6 Figures --;3 Regulation of Expression of Rat Liver Glutathione S-Transferases: Xenobiotic and Antioxidant Induction of the Ya Subunit Gene With 6 Figures --;4 Human N-Acetyltransferases With 3 Figures --;5 Genetic Regulation of the Subcellular Localization and Expression of Glucuronidase With 5 Figures --;6 Microsomal Amidases and Carboxylesterases With 5 Figures --;7 O-, N, and S-Methyltransferases With 2 Figures --;Section II: Regulation of Phase II Conjugation: Deconjugation Reactions in Intact Cells and Tissues --;8 Cofactor Supply as a Rate-Limiting Determinant of Hepatic Conjugation Reactions With 5 Figures --;9 Regulation of Drug Conjugate Production by Futile Cycling in Intact Cells With 4 Figures --;10 Pharmacokinetic Modeling of Drug Conjugates With 22 Figures --;11 Regulation of Drug Conjugate Processing by Hepatocellular Transport Systems With 1 Figure --;Section III: Pharmacology and Toxicology of Drug Conjugates --;12 Biologically Active Conjugates of Drugs and Toxic Chemicals With 5 Figures --;13 Acyl Glucuronides as Chemically Reactive Intermediates With 10 Figures --;14 Roles of Uridine Diphosphate Glucuronosyltransferases in Chemical Carcinogenesis With 9 Figures --;15 Sulfonation in Chemical Carcinogenesis With 11 Figures --;16 Glutathione Conjugate-Mediated Toxicities With 8 Figures --;17 Challenges and Directions for Future Research.

Text of Note

In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology.

Parallel Title

ConjugationDeconjugation Reactions in Drug Metabolism and Toxicity;Handbook of Experimental Pharmacology, vol. 112

Medicine.

Nuclear medicine.

Toxicology.

Class number

Book number

edited by Frederick C. Kauffman.

Frederick C Kauffman

Electronic name

[Book]

Y