Development of X-Ray Methods for the Investigation of Protein Dynamics
[Thesis]
Wolff, Alexander Michael
Fraser, James S.
University of California, San Francisco
2020
167
Ph.D.
University of California, San Francisco
2020
Throughout history, methodological innovations have resulted in breakthroughs in our understanding of biology. Methods for determining static protein structures, as well as those for probing protein dynamics, are well-established. Nonetheless, visualizing molecules as dynamic entities that respond to their environment is still an outstanding challenge. Specifically, it is challenging to measure the spatial position of all the atoms within a molecule as a function of time. That challenge is the broad focus of this dissertation.