Development of X-Ray Methods for the Investigation of Protein Dynamics
General Material Designation
[Thesis]
First Statement of Responsibility
Wolff, Alexander Michael
Subsequent Statement of Responsibility
Fraser, James S.
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
University of California, San Francisco
Date of Publication, Distribution, etc.
2020
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
167
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
Ph.D.
Body granting the degree
University of California, San Francisco
Text preceding or following the note
2020
SUMMARY OR ABSTRACT
Text of Note
Throughout history, methodological innovations have resulted in breakthroughs in our understanding of biology. Methods for determining static protein structures, as well as those for probing protein dynamics, are well-established. Nonetheless, visualizing molecules as dynamic entities that respond to their environment is still an outstanding challenge. Specifically, it is challenging to measure the spatial position of all the atoms within a molecule as a function of time. That challenge is the broad focus of this dissertation.