عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
LA5938q4rj
انگلیسی
Guttate leukoderma and acrokeratosis verruciformis of Hopf: a rare combination in Darier disease
[Article]
Sun, Christina W; Grossman, Shoshana K; Valdes-Rodriguez, Rodrigo; Lee, Jason B; Hsu, Sylvia
A distinct Darier phenotype presenting with confetti-like hypopigmented macules was first described in 1965. Designated as ''guttate leukoderma,'' this skin finding is a rarely-reported presentation of Darier disease. It has been theorized that the mutation in ATP2A2 causes defective E-cadherin, which in turn disrupts the adhesion of melanocytes to keratinocytes, thus leading to impaired dendrite formation, hindered melanin transfer, and ultimately to melanocyte apoptosis. Herein, we contribute a case of a 56-year old woman who presented with the rarely-described guttate leukoderma of Darier disease and acrokeratosis verruciformis of Hopf.
2020
Dermatology Online Journal
26/1
Sun, Christina W; Grossman, Shoshana K; Valdes-Rodriguez, Rodrigo; Lee, Jason B; Hsu, Sylvia
مطالعه متن کتاب [Article]
275578
a
Y
