Guttate leukoderma and acrokeratosis verruciformis of Hopf: a rare combination in Darier disease
General Material Designation
[Article]
First Statement of Responsibility
Sun, Christina W; Grossman, Shoshana K; Valdes-Rodriguez, Rodrigo; Lee, Jason B; Hsu, Sylvia
SUMMARY OR ABSTRACT
Text of Note
A distinct Darier phenotype presenting with confetti-like hypopigmented macules was first described in 1965. Designated as ''guttate leukoderma,'' this skin finding is a rarely-reported presentation of Darier disease. It has been theorized that the mutation in ATP2A2 causes defective E-cadherin, which in turn disrupts the adhesion of melanocytes to keratinocytes, thus leading to impaired dendrite formation, hindered melanin transfer, and ultimately to melanocyte apoptosis. Herein, we contribute a case of a 56-year old woman who presented with the rarely-described guttate leukoderma of Darier disease and acrokeratosis verruciformis of Hopf.
SET
Date of Publication
2020
Title
Dermatology Online Journal
Volume Number
26/1
PERSONAL NAME - PRIMARY RESPONSIBILITY
Entry Element
Sun, Christina W; Grossman, Shoshana K; Valdes-Rodriguez, Rodrigo; Lee, Jason B; Hsu, Sylvia