عنوان

Fragment-based drug discovery /

1849739080

9781849739085

9781782620938 (PDF eISBN)

dltt

Fragment-based drug discovery /

[Book]

edited by Steven Howard, Chris Abell

xlix, 264 pages :

illustrations (colour) ;

25 cm

RSC drug discovery,

47

2041-3203 ;

Includes bibliographical references and index

Machine generated contents note: ch. 1 Different Flavours of Fragments / Claudio Dagostin -- 1.1.Fragment-Based Drug Discovery -- 1.2.Different Types of Fragments -- 1.3.How We Identify Fragments -- 1.4.Selectivity -- 1.5.Applications of Fragment-Based Methods -- 1.5.1.Assigning Function -- 1.5.2.Assessing Ligandability -- 1.5.3.Speeding Up Chemical Validation -- 1.6.Targeting Protein -- Protein Interactions and Beyond -- 1.7.Targeting Oligonucleotides -- 1.8.Concluding Remarks -- References -- ch. 2 Getting the Most Value from Your Screens: Advances in Hardware, Software, and Methodologies to Enhance Surface Plasmon Resonance Based Fragment Screening and Hit-to-Lead Support / Brandon J. Bravo -- 2.1.Introduction -- 2.2.SPR Technology as Applied to FBS -- 2.3.The Basic Screening Cascade -- 2.4.Advances in Data Reduction and Active Selection in Primary Screening -- 2.4.1.Robust Drift Correction by Local Estimation -- 2.4.2.Method #1 for Hit Detection: Box Plots --

0

Drug development

Ligands (Biochemistry)

Drug Discovery

Ligands

Abell, C.

Howard, Steven,PhD

Royal Society of Chemistry (Great Britain),publisher

20160322033443.0

rda

[Book]

Y