Metabolism, pharmacokinetics, and toxicity of functional groups :
[Book]
impact of the building blocks of medicinal chemistry in ADMET /
edited by Dennis A. Smith
Cambridge, [England] :
Royal Society of Chemistry,
2010
xiv, 530 p. :
ill. ;
25 cm
RSC drug discovery series,
no. 1
2041-3203 ;
Includes bibliographical references and index
Drugs and their structural motifs -- ADMET for the medicinal chemist -- Carboxylic acids and their bioisosteres -- Primary, secondary, and tertiary amines and their isosteres -- Sulfonamide as an essential functional group in drug design -- Influence of aromatic rings on ADME properties of drugs -- Influence of heteroaromatic rings on ADME properties -- Peptidomimetics and peptides as drugs: motifs incorporated to enhance drug characteristics -- Pharmacokinetics and metabolism of compounds that mimic enzyme transition states -- Alcohols and phenols: absorption, distribution, metabolism, and excretion -- Future targets and chemistry and ADME needs