Metabolism, pharmacokinetics, and toxicity of functional groups :
General Material Designation
[Book]
Other Title Information
impact of the building blocks of medicinal chemistry in ADMET /
First Statement of Responsibility
edited by Dennis A. Smith
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Cambridge, [England] :
Name of Publisher, Distributor, etc.
Royal Society of Chemistry,
Date of Publication, Distribution, etc.
2010
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
xiv, 530 p. :
Other Physical Details
ill. ;
Dimensions
25 cm
SERIES
Series Title
RSC drug discovery series,
Volume Designation
no. 1
ISSN of Series
2041-3203 ;
INTERNAL BIBLIOGRAPHIES/INDEXES NOTE
Text of Note
Includes bibliographical references and index
CONTENTS NOTE
Text of Note
Drugs and their structural motifs -- ADMET for the medicinal chemist -- Carboxylic acids and their bioisosteres -- Primary, secondary, and tertiary amines and their isosteres -- Sulfonamide as an essential functional group in drug design -- Influence of aromatic rings on ADME properties of drugs -- Influence of heteroaromatic rings on ADME properties -- Peptidomimetics and peptides as drugs: motifs incorporated to enhance drug characteristics -- Pharmacokinetics and metabolism of compounds that mimic enzyme transition states -- Alcohols and phenols: absorption, distribution, metabolism, and excretion -- Future targets and chemistry and ADME needs