عنوان

Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.

شماره

LA2jw7m037

عنوان اصلي

Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways.

نام عام مواد

[Article]

نام نخستين پديدآور

Fu, Dong-JunZhang, LiSong, JianMao, Ruo-WangZhao, Ruo-HanLiu, Ying-ChaoHou, Yu-HuiLi, Jia-HuanYang, Jia-JiaJin, Cheng-YunLi, PingZi, Xiao-LinLiu, Hong-MinZhang, Sai-YangZhang, Yan-Bing

متن يادداشت

A series of novel formononetin-dithiocarbamate derivatives were designed, synthesized and evaluated for antiproliferative activity against three selected cancer cell line (MGC-803, EC-109, PC-3). The first structure-activity relationship (SAR) for this formononetin-dithiocarbamate scaffold is explored in this report with evaluation of 14 variants of the structural class. Among these analogues, tert-butyl 4-(((3-((3-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl)oxy)propyl)thio)carbonothioyl)piperazine-1-carboxylate (8i) showed the best inhibitory activity against PC-3 cells (IC 50 = 1.97 μM). Cellular mechanism studies elucidated 8i arrests cell cycle at G1 phase and regulates the expression of G1 checkpoint-related proteins in concentration-dependent manners. Furthermore, 8i could inhibit cell growth via MAPK signaling pathway and inhibit migration via Wnt pathway in PC-3 cells.

تاريخ نشر

2017

عنوان

UC Irvine

نام الکترونيکي

نوع ماده

[Article]

کد کاربرگه

277837

سطح دسترسي

a

تكميل شده

Y