عنوان

Biobetters :

شابک

1493925431

شابک

9781493925438

شابک اشتباه

1493925423 (print)

شابک اشتباه

9781493925421

شابک اشتباه

9781493925421 (print)

شماره

dltt

عنوان اصلي

Biobetters :

نام عام مواد

[Book]

ساير اطلاعات عنواني

protein engineering to approach the curative /

نام نخستين پديدآور

Amy Rosenberg, Barthélemy Demeule, editors

نام خاص و کميت اثر

1 online resource (xv, 378 pages) :

ساير جزييات

color illustrations.

عنوان فروست

AAPS advances in the pharmaceutical sciences series,

مشخصه جلد

19

شاپا ي ISSN فروست

2210-7371 ;

متن يادداشت

Includes index

متن يادداشت

Introduction -- Targeting glucocerebrosidase to macrophages for effective treatment of patients with Gaucher disease: setting the paradigm of a "fit for purpose" approach to enzyme replacement therapy -- Challenges of Enzyme Replacement Therapy: Poor tissue distribution in lysosomal diseases using Pompe disease as a model -- Muscle targeting -- Blood-Brain Barrier Targeting of Therapeutic Lysosomal Enzymes -- Novel Methods for Addressing Immunogenicity in Therapeutic Enzymes -- Structure of monoclonal antibodies -- Prediction of aggregation in vivo by studies of therapeutic proteins in human plasma -- Effect of Hydrolytic Degradation on the In Vivo Properties of Monoclonal Antibodies -- Oxidation of proteins in the in-vivo environment: what we know; what we need to study and potential mitigation strategies -- Molecular assessment: balancing affinity, PK and manufacturability -- Perspectives on engineering biobetter therapeutic proteins with greater stability in inflammatory environments -- Antibody-like molecules designed for superior targeting and pharmacokinetics -- Alternative protein scaffolds as novel biotherapeutics -- Current strategies for pharmacokinetic optimization -- Biosimilar and Biobetter Scenarios for the US and Europe: What Should We Expect? -- Regulatory considerations for approval of biobetter products

بدون عنوان

0

شماره استاندارد بين المللي کتاب و موسيقي

9781493925421

موضوع مستند نشده

Protein drugs.

موضوع مستند نشده

Protein engineering.

موضوع مستند نشده

Proteins-- Biotechnology.

موضوع مستند نشده

SCI-- 013060

موضوع مستند نشده

TEC-- 009010

شماره

ويراست

شماره رده

مستند نام اشخاص تاييد نشده

Demeule, Barthélemy

مستند نام اشخاص تاييد نشده

Rosenberg, Amy

مستند نام تنالگان تاييد نشده

Ohio Library and Information Network.

تاريخ عمليات

20201222111555.6

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

کد کاربرگه

270410

تكميل شده

Y