xiii, 438 p., [16] p. of plates , ill. (some col.) , 29 cm.
یادداشتهای مربوط به نشر، بخش و غیره
متن يادداشت
Print
یادداشتهای مربوط به کتابنامه ، واژه نامه و نمایه های داخل اثر
متن يادداشت
Includes bibliographical references and index.
یادداشتهای مربوط به مندرجات
متن يادداشت
Section VI. Protease Inhibitors: Discovery and development of telaprevir -- Discovery and development of BILN 2061 and follow-up BI 201335 -- Intervention of Hepatitis C replication through NS3-4A, the protease inhibitor boceprevir -- Discovery and development of the HCV NS3/4A protease inhibitor danoprevir (ITMN-191/RG7227) -- Discovery and development of the HCV protease inhibitor TMC435 -- Section VII. HCV Polymerase Nucleoside Inhibitors: Discovery and clinical evaluation of the nucleoside analog balapiravir (R1626) for the treatment of HCV infection -- Discovery and development of PSI-6130/RG7128 -- Section VIII. Other HCV Inhibitors: Discovery of Cyclophilin inhibitor NIM811 as a novel therapeutic agent for HCV -- HCV viral entry inhibitors -- Discovery of the RSV inhibitor TMC353121 -- Discovery and development of orally active RSV fusion inhibitors -- Discovery and development of RSV604 -- Discovery and development of influenza virus sialidase inhibitor relenza -- Discovery and development of entecavir -- Benzimidazole ribonucleosides: novel drug candidates for the prevention and treatment of cytomegalovirus diseases.
متن يادداشت
Section 1. HIV Protease Inhibitors: Discovery and development of atazanavir -- Discovery and development of PL-100, a novel HIV-1 protease inhibitor -- Darunavir (Prezista, TMC114): from bench to clinic, improving treatment options for HIV-infected patients -- Discovery and development of tipranavir -- Section II. HIV Non-nucleoside Reverse Transcriptase Inhibitors: TMC278 (Rilpivirine): a next-generation NNRTI in phase III clinical development for treatment-naive patients -- Entravirine: from TMC125 to intelence: a treatment paradigm shift for HIV-infected patients -- Section III. HIV Nucleoside Reverse Transcriptase Inhibitors: Discovery and development of tenovir disoproxil fumarate -- Discovery and development of apricitabine -- Section IV. HIV Entry Inhibitors: Discovery and development of maraviroc and PF-232798: CCR5 antagonists for the treatment of HIV-1 infection -- Discovery of the CCR5 antagonist vicriviroc (Sch 417690/Sch-D) for the treatment of HIV-1 infection -- Discovery and development of HIV-1 entry inhibitors that target gp120 -- Section V. HIV Integrase Inhibitors: Discovery of MK-0536: a potential second-generation HIV-1 integrase strand transfer inhibitor with a high genetic barrier to mutation -- Discovery and development of HIV integrase inhibitor raltegravir -- Elvitegravir: a novel monoketo acid HIV-1 integrase strand transfer inhibitor --