عنوان

Studies on inhibin in the Syrian hamster Mesocricetus auratus

شماره

TLpq304094091

زبان متن نوشتاري يا گفتاري و مانند آن

انگلیسی

عنوان اصلي

Studies on inhibin in the Syrian hamster Mesocricetus auratus

نام عام مواد

[Thesis]

نام نخستين پديدآور

M. E. McAsey

نام ساير پديدآوران

B. Benson

نام ناشر، پخش کننده و غيره

The University of Arizona

تاریخ نشرو بخش و غیره

1994

نام خاص و کميت اثر

140

جزئيات پايان نامه و نوع درجه آن

Ph.D.

کسي که مدرک را اعطا کرده

The University of Arizona

امتياز متن

1994

متن يادداشت

Inhibin is a heterodimeric glycoprotein which may regulate FSH synthesis and secretion as well as follicular development and maturation. The source and physiological role of inhibin have not been established for the hamster, although several investigators have suggested that this hormone may function in the regulation of FSH in this species. The major objectives of these studies were to develop a radioimmunoassay (RIA) for the measurement of inhibin-a in hamster serum and tissue, to identify the primary source of inhibin and to examine the relationship between inhibin and FSH during postnatal development. A sensitive, accurate and specific RIA was developed and utilized to measure changes in circulating levels of inhibin-a following bilateral gonadectomy, in developing hamsters and in studies on inhibin throughout the estrous cycle. Circulating inhibin-a declined rapidly and significantly following bilateral gonadectomy in male and female hamsters suggesting a gonadal source. Serum FSH concentrations increased following the decline in serum inhibin-a levels. An inverse relationship between inhibin and FSH was observed in early postnatal development. Male hamsters exhibited high serum concentrations of inhibin-usd\alphausd and low concentrations of FSH prior to the third postnatal week. Young female hamsters exhibited low concentrations of circulating inhibin-usd\alphausd and early, high levels of FSH. With follicular stimulation prior to the first ovulation, ovarian and serum inhibin concentrations increased and serum FSH was suppressed suggesting a possible endocrine regulatory role for inhibin. Administration of PMSG to peripubertal female hamsters increased ovarian and serum levels of inhibin-usd\alphausd, and increased steady-state levels of inhibin subunit mRNAs. Elevated levels of immunoreactive inhibin-usd\alphausd in PMSG-treated hamsters were inversely correlated with serum FSH concentrations, providing evidence for the reciprocal relationship between inhibin and FSH. Immunoreactive inhibin-a increased gradually throughout diestrus in the hamster. Inhibin-usd\alphausd concentrations peaked in the circulation at the time of the preovulatory gonadotropin surge, then declined to a nadir on the morning of estrus. Significant reductions in serum concentrations of inhibin-usd\alphausd during early estrus may moderate the amount and duration of the secondary FSH rise and thus contribute to the regulation of follicle recruitment.

موضوع مستند نشده

Biological sciences

موضوع مستند نشده

Molecular biology

موضوع مستند نشده

Zoology

موضوع مستند نشده

Zoology

مستند نام اشخاص تاييد نشده

B. Benson

مستند نام اشخاص تاييد نشده

M. E. McAsey

نام الکترونيکي

فرمت انتشار

p

نوع ماده

[Thesis]

کد کاربرگه

276903

سطح دسترسي

a

تكميل شده

Y