Voltammetric assays and behavior of norfloxacin and nalidixic acid antibacterial drugs
نام عام مواد
[Thesis]
نام نخستين پديدآور
A. Lounici
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
King Fahd University of Petroleum and Minerals (Saudi Arabia)
تاریخ نشرو بخش و غیره
1993
مشخصات ظاهری
نام خاص و کميت اثر
216
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
M.S.
کسي که مدرک را اعطا کرده
King Fahd University of Petroleum and Minerals (Saudi Arabia)
امتياز متن
1993
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
This thesis describes the work done on the voltammetric assays, physicochemical behavior, and mechanistic studies of norfloxacin and nalidixic and antibacterial drugs at the dropping mercury electrode (DME) and at the hanging mercury drop electrode (HMDE). Easy, precise, accurate and fast analytical procedures have been developed for the quantitative determination of norfloxacin and nalidixic acid in formulated tablets using differential pulse polarography (DPP), linear scan voltammetry (LSV) and adsorptive striping voltammetry (AdSV). Good working ranges and recoveries with small standard deviations were obtained in the determination of both antibacterials using DPP and LSV techniques with a detection limit of 1 ppm (1 mg/l). Determination of ultra-trace of norfloxacin was possible using the AdSV with a detection limit of 0.31 ppt (0.31 ng/l). The voltammetric behavior and mechanistic study of norfloxacin and nalidixic acid were investigated. Norfloxacin was found to be reduced in one electron step in strongly acidic and in alkaline solution. However, it is reduced in 2 one electron steps in slightly acidic to slightly alkaline solutions (pH 5.5-8.0). The two main reduction waves were found to be irreversible and diffusion controlled with scan rates >20 mV/sec. However, the other smaller waves showed different degree of reversibility depending on the scan rate and were found to be adsorption controlled. Nalidixic acid is found to be reduced in 2 one electron steps in strongly acidic medium and in slightly acidic to slightly alkaline solutions. However, it is reduced in one electron only in alkaline solutions. Its reduction processes were found to be completely irreversible and diffusion controlled.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Chemistry
موضوع مستند نشده
Pure sciences
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )