عنوان

In-Vivo Studies of the Trypanocidal and Toxicity Activities of Aframomum melegueta (Alligator Pepper)

شماره

TLpq2516283728

زبان متن نوشتاري يا گفتاري و مانند آن

انگلیسی

عنوان اصلي

In-Vivo Studies of the Trypanocidal and Toxicity Activities of Aframomum melegueta (Alligator Pepper)

نام عام مواد

[Thesis]

نام نخستين پديدآور

Ogunlusi, Blessing Omolara

نام ساير پديدآوران

Ojo, Sunday

نام ناشر، پخش کننده و غيره

Kwara State University (Nigeria)

تاریخ نشرو بخش و غیره

2021

نام خاص و کميت اثر

149

جزئيات پايان نامه و نوع درجه آن

M.S.

کسي که مدرک را اعطا کرده

Kwara State University (Nigeria)

امتياز متن

2021

متن يادداشت

Trypanosomiasis is a disease caused by a bite from an infected tsetse fly and infect ruminant animals and also human. Herbal medicines are popularly used remedies for many diseases by a vast majority of the world's population, because allopathic medicines have large number of side-effects. It is in view of this that this study evaluates the in-vivo studies of the Trypanocidal and toxicity activities of Aframomum melegueta (Alligator Pepper). Seeds of Aframomum melegueta were sundried and grounded. The powdered seed was used for phytochemical analysis using methanol under standard procedures, to determine both the quantitative and qualitative component of the seed. Rats for the experiment were gotten from the animal unit of the Biochemistry Department of University of Ilorin, and were infected with Trypanosoma brucei brucei parasite obtained from stabilates maintained at the Nigerian Institute for Trypanosomiasis Research (NITR), Vom, Plateau State, Nigeria through transverse passage. Thirty rats were used, and were grouped into six groups, (group A-F) and were inoculated intraperitoneally with trypanosomes (2.5×104). The rats were screened for trypanosomes three days post infection using rapid matching counting method. When parasitaemia count was 5×108 trypanosomes/ml on day 9 post infection. Rats in Group A-E were treated with 0.1 ml, 0.2 mls, 0.3 mls, 0.4 mls and 0.5 msl of methanolic seed extract of Aframomum melegueta through the oral route while Group F infected untreated (control group) received normal saline alone all through. Rats were monitored daily, during and after treatment for Parasitaemia and packed cell volume (PCV) for 60 days. Dead rats were disserted and the liver examined for histopathology. Results reveal that Aframomum melegueta contains compounds which make it a promising antitrypanocidal medicine but with a damaging effect on the liver of rats which could result to their mortality if consumed in large quanties.

موضوع مستند نشده

Zoology

مستند نام اشخاص تاييد نشده

Ogunlusi, Blessing Omolara

مستند نام اشخاص تاييد نشده

Ojo, Sunday

نام الکترونيکي

فرمت انتشار

p

نوع ماده

[Thesis]

کد کاربرگه

276903

سطح دسترسي

a

تكميل شده

Y