عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TLpq2364139694
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
The Role of Atypical Protein Kinase C in Colorectal Cancer Cells Carcinogenesis
نام عام مواد
[Thesis]
نام نخستين پديدآور
Islam, S. M. Anisul Anisul
نام ساير پديدآوران
Acevedo-Duncan, Mildred
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
University of South Florida
تاریخ نشرو بخش و غیره
2019
مشخصات ظاهری
نام خاص و کميت اثر
164
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
Ph.D.
کسي که مدرک را اعطا کرده
University of South Florida
امتياز متن
2019
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Colorectal cancer (CRC) is the third most common malignancy and the fourth most common cause of cancer-related death worldwide. CRC is a life-threatening disease due to therapy-resistant cancerous cells. The exact mechanisms of cell growth, survival, metastasis and inter & intracellular signaling pathways involved in CRC are still a significant challenge. Moreover, the treatment of metastatic CRC considered palliative for many years aimed for an improved life, with little hope of a cure, highlighting the need for developing novel targeted therapy for CRC. Hence, investigating new molecular mechanism(s) that lead to colorectal carcinogenesis may give insight into the therapeutic target. Human protein kinases constitute a complicated system with complex internal and external interactions, which stimulates various cellular processes such as cell growth, metabolism, survival, and apoptosis. In this study, the role of atypical Protein Kinase C (aPKC) on CRC was investigated by using two inhibitors: 1) ICA-I, an inhibitor of PKC-ι, and 2) ζ-Stat, an inhibitor of PKC-ζ. The cell lines tested were CCD18CO normal colorectal; and LoVo and RKO metastatic CRC cells. Our findings suggest that the aPKCs are responsible for the abnormal growth, proliferation, and metastasis of metastatic CRC cells via aPKC/Rac1/Pak1/β-Catenin pathway and aPKC/Slingshot/cofilin pathways. Moreover, the combination of aPKC inhibitors works synergistically with the clinically available drug such as 5-Fluorouracil (5-FU) to retard the proliferation and induce massive apoptosis in CRC cells. However, the inhibition of aPKCs did not bring any significant toxicity on CCD18CO healthy cells. These results suggest the possibility of utilizing PKC-ζ inhibitor to block CRC cell growth, proliferation, and metastasis.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Biochemistry
موضوع مستند نشده
Cellular biology
موضوع مستند نشده
Oncology
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
Acevedo-Duncan, Mildred
مستند نام اشخاص تاييد نشده
Islam, S. M. Anisul Anisul
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
