Reducing Antibiotic Consumption in Patients with Asymptomatic Bacteriuria:
نام عام مواد
[Thesis]
نام نخستين پديدآور
Mozafarihashjin, Mohammad
عنوان اصلي به قلم نويسنده ديگر
A Bi-directional Approach
نام ساير پديدآوران
McGeer, Allison Joan
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
University of Toronto (Canada)
تاریخ نشرو بخش و غیره
2019
مشخصات ظاهری
نام خاص و کميت اثر
146
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
M.Sc.
کسي که مدرک را اعطا کرده
University of Toronto (Canada)
امتياز متن
2019
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Objectives: To assess safety and effectiveness of not processing midstream urine (MSU) in adults to reduce asymptomatic bacteriuria (ASB) treatment, and find a biomarker that differentiates symptomatic urinary tract infection (SUTI) from ASB in adults. Methods: From 11/2013-04/2019 MSU for surgical/medical in-patients were routinely not processed. Patients were followed up for 4 and 30 days. Primary outcome was safety; secondary outcomes were antibiotic use, lab workload, and rate/proportion of MSU submitted/processed. A systematic review was conducted to identify potential biomarkers. Results: In 912 patients, no serious adverse events (AE) and 6 (0.66%) non-serious AE occurred due to not processing MSU. Processed MSU proportion, submitted MSU rate, and lab workload decreased (P=0.002; P=0.02; 5 person-days/year). Ninety-eight patients avoided antibiotics. Urine IL-6 and IL-8 were the most promising biomarkers. Conclusion: Not processing MSU reduces ASB treatment safely and effectively. Urine IL-6 and IL-8 could possibly differentiate ASB from SUTI.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Epidemiology
موضوع مستند نشده
Health sciences
موضوع مستند نشده
Medicine
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )