عنوان

Aspergillus: Interactions among Biofilms, Oxygen, Antifungal Drugs and Melanin

شماره

TL52049

زبان متن نوشتاري يا گفتاري و مانند آن

انگلیسی

عنوان اصلي

Aspergillus: Interactions among Biofilms, Oxygen, Antifungal Drugs and Melanin

نام عام مواد

[Thesis]

نام نخستين پديدآور

Dávila González, María M.

نام ساير پديدآوران

Bayman, Paul

نام ناشر، پخش کننده و غيره

University of Puerto Rico, Rio Piedras (Puerto Rico)

تاریخ نشرو بخش و غیره

2019

متن يادداشت

101 p.

جزئيات پايان نامه و نوع درجه آن

M.S.

کسي که مدرک را اعطا کرده

University of Puerto Rico, Rio Piedras (Puerto Rico)

امتياز متن

2019

متن يادداشت

Aspergillus fungi opportunistic pathogenesis often involves the formation of biofilms and adaptation to low oxygen environments to survive in the human body. However, interactions between biofilms and low oxygen are not well understood. In the first chapter, we studied biofilm formation by A. fumigatus, A. niger, A. flavus, and A. terreus in microaerophilic conditions. All species formed biofilms in microaerophilic conditions. In the second chapter we compared resistance to Amphotericin B in different conditions. A. flavus was more resistant to AMB than A. fumigatus in microaerophilic conditions. In the third chapter, we studied the roles of melanin in biofilm formation and virulence. We evaluate biofilms formation of A. fumigatus mutants deficient in pyomelanin (hppd) and DHN-melanin (alb1). Melanin was not crucial for biofilm formation. Also, the alb1 mutant was more virulent in Drosophila melanogaster than several wild type strains. These data support why aspergillosis infections are challenging to eradicate.

اصطلاح موضوعی

Biology

اصطلاح موضوعی

Microbiology

مستند نام اشخاص تاييد نشده

Dávila González, María M.

مستند نام اشخاص تاييد نشده

Bayman, Paul

مستند نام تنالگان تاييد نشده

University of Puerto Rico, Rio Piedras (Puerto Rico)

نام الکترونيکي

فرمت انتشار

p

نوع ماده

[Thesis]

کد کاربرگه

276903

سطح دسترسي

a

تكميل شده

Y