عنوان

Pre-implant Brain Activation Modeling to Drive Placement of Depth Leads in White Matter for Direct Neurostimulation Therapy in Epilepsy

شماره

TL50822

زبان متن نوشتاري يا گفتاري و مانند آن

انگلیسی

عنوان اصلي

Pre-implant Brain Activation Modeling to Drive Placement of Depth Leads in White Matter for Direct Neurostimulation Therapy in Epilepsy

نام عام مواد

[Thesis]

نام نخستين پديدآور

Cendejas Zaragoza, Leopoldo

نام ساير پديدآوران

Rossi, Marvin A.

نام ناشر، پخش کننده و غيره

Illinois Institute of Technology

تاریخ نشرو بخش و غیره

2019

متن يادداشت

213 p.

جزئيات پايان نامه و نوع درجه آن

Ph.D.

کسي که مدرک را اعطا کرده

Illinois Institute of Technology

امتياز متن

2019

متن يادداشت

A critical step towards applying direct brain stimulation therapy in focal onset epilepsy is to effectively interface with epileptogenic neural circuits using a limited set of active contacts. This takes special relevance when interacting with networks that exhibit two or more foci. A strategy to influence the maximum extent of the epileptogenic circuit is to stimulate white matter pathways to enhance propagation to distant epileptic tissue. A significant number of elements must be considered in the clinical response to stimulation delivered directly to neuronal populations. These variables include: stimulation parameter settings, number and interdependence of anatomical targets, electrode number, electrode location and orientation, geometry or shape of the electrode contacts, contact polarity, biophysical properties of stimulated medium, and trajectory of axonal bundles adjacent to the stimulation site. This document addresses the development of a computational model which takes into consideration all the mentioned variables to predict activation of distant sites via white matter pathways. A method to calculate the extracellular potential field, induced by the application of time-dependent stimulation waveforms, is discussed. Such a method considers both the anisotropic conductivity nature of neural tissue and the electrochemical phenomena of the electrode-tissue interface. The response of white matter fibers is then evaluated by solving a compartmental cable model based in the Hodgkin and Huxley membrane description. The model was integrated into a pre-surgical workflow and was used prospectively to guide stereotactic implantation of depth leads to apply direct neurostimulation therapy in four patients with refractory focal onset epilepsy.

اصطلاح موضوعی

Biomedical engineering

اصطلاح موضوعی

Medicine

اصطلاح موضوعی

Neurosciences

مستند نام اشخاص تاييد نشده

Cendejas Zaragoza, Leopoldo

مستند نام اشخاص تاييد نشده

Rossi, Marvin A.

مستند نام تنالگان تاييد نشده

Illinois Institute of Technology

نام الکترونيکي

فرمت انتشار

p

نوع ماده

[Thesis]

کد کاربرگه

276903

سطح دسترسي

a

تكميل شده

Y