عنوان

Bone Perfusion Alterations in Chronic Kidney Disease

شماره

TL50647

زبان متن نوشتاري يا گفتاري و مانند آن

انگلیسی

عنوان اصلي

Bone Perfusion Alterations in Chronic Kidney Disease

نام عام مواد

[Thesis]

نام نخستين پديدآور

Aref, Mohammad W.

نام ساير پديدآوران

Allen, Matthew R.

نام ناشر، پخش کننده و غيره

Indiana University - Purdue University Indianapolis

تاریخ نشرو بخش و غیره

2019

متن يادداشت

138 p.

جزئيات پايان نامه و نوع درجه آن

Ph.D.

کسي که مدرک را اعطا کرده

Indiana University - Purdue University Indianapolis

امتياز متن

2019

متن يادداشت

Patients with chronic kidney disease (CKD) are at an alarming risk of fracture and cardiovascular disease-associated mortality. There is a critical need to better understand the underlying mechanism driving altered cardiovascular and skeletal homeostasis, as well as any connection between the two. CKD has been shown to have negative effects on many vascular properties including end-organ perfusion. Surprisingly, exploration of skeletal perfusion and vasculature has not been undertaken in CKD. Alterations in bone perfusion are linked to dysregulation of bone remodeling and mass in multiple conditions. An understanding of the detrimental impact of CKD on bone perfusion is a crucial step in understanding bone disease in these patients. The goal of this series of studies was to test the global hypothesis that skeletal perfusion is altered in CKD and that alterations can be modulated through treatments that affect metabolic dysfunction. These studies utilized a rat model of CKD to conduct metabolic assessments, bone perfusion measurements, bone imaging studies, and isolated vessel reactivity experiments. Our results showed that animals with CKD had higher levels of parathyroid hormone (PTH), leading to substantial bone resorption. Bone perfusion measurements showed CKD-induced elevations in cortical bone perfusion with levels progressing alongside CKD severity. Conversely we show that marrow perfusion was lower in advanced CKD. PTH suppression therapy in animals with CKD resulted in the normalization of cortical bone perfusion and cortical bone mass, but did not normalize marrow bone perfusion. These results show a clear association between bone deterioration and altered bone perfusion in CKD. While the relationship of altered bone perfusion and bone deterioration in CKD necessitates further work, these results indicate that determining the mechanisms of bone perfusion alterations and whether they are drivers, propagators, or consequences of skeletal deterioration in CKD could help untangle a key player in CKD-induced bone alterations.

اصطلاح موضوعی

Medicine

مستند نام اشخاص تاييد نشده

Aref, Mohammad W.

مستند نام اشخاص تاييد نشده

Allen, Matthew R.

مستند نام تنالگان تاييد نشده

Indiana University - Purdue University Indianapolis

نام الکترونيکي

فرمت انتشار

p

نوع ماده

[Thesis]

کد کاربرگه

276903

سطح دسترسي

a

تكميل شده

Y