عنوان

Ligand-macromolecular interactions in drug discovery :

شابک

1607612445

شابک

9781607612445

شابک اشتباه

1607612437

شابک اشتباه

9781607612438

شماره

b700600

عنوان اصلي

Ligand-macromolecular interactions in drug discovery :

نام عام مواد

[Book]

ساير اطلاعات عنواني

methods and protocols /

نام نخستين پديدآور

edited by Ana Cećilia A. Roque.

محل نشرو پخش و غیره

New York, NY :

نام ناشر، پخش کننده و غيره

Humana Press,

تاریخ نشرو بخش و غیره

©2010.

نام خاص و کميت اثر

1 online resource (x, 297 pages) :

ساير جزييات

illustrations

عنوان فروست

Methods in molecular biology,

عنوان فروست

Springer protocols

مشخصه جلد

572

شاپا ي ISSN فروست

1064-3745 ;

متن يادداشت

Includes bibliographical references and index.

متن يادداشت

Part I. Reviews -- 1. An Historical overview of drug discovery / Ana Sofia Pina, Abid Hussain, and Ana Cecília Roque -- 2. Ligand mcromolecule iteractions : theoretical principles of molecular recognition / Tammy Nolan, Nidhi Singh, and Christopher R. McCurdy -- 3. X-Ray cystallography in drug discovery / Ana Luísa Carvalho, José Trincão, and Maria João Romão -- 4. Virtual screening of compound libraries / Nuno M.F.S.A. Cerqueira, Sérgio F. Sousa, Pedro A. Fernandes, and Maria João Ramos -- Part II: Protocols -- 5. Combinatorial chemistry and the synthesis of compound libraries / Rolf Breinbauer and Matthias Mentel -- 6. Ligand-based nuclear magnetic resonance screening techniques / Aldino Viegas, Anjos L. Macedo, and Eurico Cabrita -- 7. Isothermal titration calorimetry and differential scanning calorimetry / Geoff Holdgate -- 8. Adaptive combinatorial design of focused compound libraries / Gisbert Schneider and Andreas Schüller -- 9. Chemical microarrays : a new tool for discovery enzyme inhibitors / Shuguang Liang, Wei Xu, Kurumi Y. Horiuchi, Yuan Wang, and Haiching Ma -- 10. Fluorescence polarization and time-resolved fluorescence resonance energy transfer techniques for PI3K assays / Kurumi Y. Horiuchi and Haiching Ma -- 11. Small molecule protein interaction profiling with functional protein microarrays / Lihao Meng, Dawn Mattoon, and Paul Predki -- 12. Capillary electrophoresis in drug discovery / Milena Quaglia and Ersilia De Lorenzi -- 13. SPR in drug discovery : searching bioactive compounds in plant extracts / Maria Minunni and Anna Rita Bilia -- 14. Application of frontal affinity chromatography with mass spectrometry (FAC-MS) for stereospecific ligand-macromolecule interaction, detection and screening / Jacek Slon-Usakiewicz and Peter Redden -- 15. GPC spin column HPLC-ESI-MS methods for screening drugs noncovalently bound to proteins / Marshall M. Siegel -- 16. A scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening / Yuren Wang and Philip Jones -- 17. A natural products approach to drug discovery : probing modes of action of antitumor agents by genome-scale cDNA library screening / Hendrik Luesch and Pedro Abreu -- 18. Ligand-macromolecule interactions in live cells by fluorescence correlation spectroscopy / Aladdin Pramanik.

بدون عنوان

0

متن يادداشت

Drug research has been greatly transformed by the "omics revolution" and advances in computational tools, combinatorial chemistry, and high throughput screening techniques (HTS). These implements have advanced the ability to identify target molecules that serve as points of attack for future medicines, the design and synthesis of potential lead compounds, and further characterization, screening, and assays for therapeutic efficacy and toxicity. In Ligand-Macromolecular Interactions in Drug Discovery: Methods and Protocols, experts in the field highlight the main principles and methodologies currently utilized in the study of molecular interactions between compounds, either natural or synthetic, and complementary biological targets, within the scope of drug discovery. Beginning with a historical perspective of drug research focusing on the contribution of genomics, proteomics, high-throughput methods, and computational developments in drug discovery, the book then delves into highly detailed methods on topics such as NMR spectroscopy, compound library design and synthesis, chemical and biological microarrays, and many others. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Ligand-Macromolecular Interactions in Drug Discovery: Methods and Protocols will serve as an ideal guide to scientists in academia and in industry who are striving to further our knowledge of medicines.

منبع سفارش / آدرس اشتراک

Springer

شماره انبار

978-1-60761-243-8

عنوان

Ligand-macromolecular interactions in drug discovery.

شماره استاندارد بين المللي کتاب و موسيقي

9781607612438

موضوع مستند نشده

Drug development.

موضوع مستند نشده

Ligand binding (Biochemistry)

موضوع مستند نشده

Macromolecules.

موضوع مستند نشده

Analytical, Diagnostic and Therapeutic Techniques and Equipment

موضوع مستند نشده

Biological Science Disciplines.

موضوع مستند نشده

Chemical Actions and Uses

موضوع مستند نشده

Chemicals and Drugs

موضوع مستند نشده

Chemistry, Pharmaceutical.

موضوع مستند نشده

Chemistry.

موضوع مستند نشده

Clinical Laboratory Techniques.

موضوع مستند نشده

Disciplines and Occupations

موضوع مستند نشده

Drug Discovery.

موضوع مستند نشده

Investigative Techniques

موضوع مستند نشده

Laboratory Chemicals.

موضوع مستند نشده

Ligands.

موضوع مستند نشده

Macromolecular Substances.

موضوع مستند نشده

Natural Science Disciplines.

موضوع مستند نشده

Pharmacology.

موضوع مستند نشده

Specialty Uses of Chemicals

موضوع مستند نشده

Drug development.

موضوع مستند نشده

Health & Biological Sciences.

موضوع مستند نشده

Ligand binding (Biochemistry)

موضوع مستند نشده

Macromolecules.

موضوع مستند نشده

Pharmacy, Therapeutics, & Pharmacology.

موضوع مستند نشده

MED071000

موضوع مستند نشده

MMG

شماره

ويراست

شماره رده

نشانه اثر

شماره رده

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Roque, Ana Cecília A., (Ana Cecília Afonso)

تاريخ عمليات

20201207162410.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y