عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
LA9px8g3xm
عنوان و نام پديدآور
عنوان اصلي
Analysis of the genetic basis of height in large Jewish nuclear families.
نام عام مواد
[Article]
نام نخستين پديدآور
Zeevi, Danny; Bloom, Joshua S; Sadhu, Meru J; Ben Yehuda, Adi; Zangen, David; Levy-Lahad, Ephrat
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
Despite intensive study, most of the specific genetic factors that contribute to variation in human height remain undiscovered. We conducted a family-based linkage study of height in a unique cohort of very large nuclear families from a founder (Jewish) population. This design allowed for increased power to detect linkage, compared to previous family-based studies. Loci we identified in discovery families could explain an estimated lower bound of 6% of the variance in height in validation families. We showed that these loci are not tagging known common variants associated with height. Rather, we suggest that the observed signals arise from variants with large effects that are rare globally but elevated in frequency in the Jewish population.
مجموعه
تاريخ نشر
2019
عنوان
Lawrence Berkeley National Laboratory
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب اطلاعات رکورد کتابشناسی
نوع ماده
[Article]
کد کاربرگه
275578
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
