عنوان

The elementome of calcium-based urinary stones and its role in urolithiasis

شماره

LA5bd195fh

عنوان اصلي

The elementome of calcium-based urinary stones and its role in urolithiasis

نام عام مواد

[Article]

نام نخستين پديدآور

Ramaswamy, K; Killilea, DW; Kapahi, P; Kahn, AJ; Chi, T; Stoller, ML

متن يادداشت

© 2015 Macmillan Publishers Limited. Urolithiasis affects around 10% of the US population with an increasing rate of prevalence, recurrence and penetrance. The causes for the formation of most urinary calculi remain poorly understood, but obtaining the chemical composition of these stones might help identify key aspects of this process and new targets for treatment. The majority of urinary stones are composed of calcium that is complexed in a crystalline matrix with organic and inorganic components. Surprisingly, mitigation of urolithiasis risk by altering calcium homeostasis has not been very effective. Thus, studies to identify other therapeutic stone-specific targets, using proteomics, metabolomics and microscopy techniques, have been conducted, revealing a high level of complexity. The data suggest that numerous metals other than calcium and many nonmetals are present within calculi at measurable levels and several have distinct distribution patterns. Manipulation of the levels of some of these elemental components of calcium-based stones has resulted in clinically beneficial changes in stone chemistry and rate of stone formation. The elementome - the full spectrum of elemental content - of calcium-based urinary calculi is emerging as a new concept in stone research that continues to provide important insights for improved understanding and prevention of urinary stone disease.

تاريخ نشر

2015

عنوان

UCSF

نام الکترونيکي

نوع ماده

[Article]

کد کاربرگه

275578

سطح دسترسي

a

تكميل شده

Y