عنوان

Development of a New Heterocycle-Forming Reaction and Kinetic Resolution with N-Heterocyclic Carbenes /

شابک

9789811393983

شابک

9789811393990

شابک

9789811394003

شابک

9811393982

شابک

9811393990

شابک

9811394008

شابک اشتباه

9789811393976

شابک اشتباه

9811393974

عنوان اصلي

Development of a New Heterocycle-Forming Reaction and Kinetic Resolution with N-Heterocyclic Carbenes /

نام عام مواد

[Book]

نام نخستين پديدآور

Yinli Wang.

محل نشرو پخش و غیره

Singapore :

نام ناشر، پخش کننده و غيره

Springer,

تاریخ نشرو بخش و غیره

2019.

نام خاص و کميت اثر

1 online resource (118 pages)

عنوان فروست

Springer Theses

متن يادداشت

"Doctoral thesis accepted by the University of Kyoto, Kyoto, Japan."

متن يادداشت

Introduction -- Oxa- and Azacycle-formation via Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide -- Kinetic Resolution of #x1B;(Sa#x1B;(B-Hydroxy Carboxylic Acid Derivatives Based on Chiral Recognition of Substrate-Cocatalyst Complex -- Conclusion -- Experimental Section.

بدون عنوان

0

متن يادداشت

In this book, the author focuses on exploring new organocatalytic transformations under operationally simple and environmentally friendly reaction conditions. Two new types of catalytic reactions promoted by N-heterocyclic carbenes (NHCs) are described. The oxa- and azacycle-forming reactions of sulfonylalkynols and sulfonylalkynamides are broadly considered to be a new type of activation mode in NHC chemistry, wherein the bond formation with internal O- and N-nucleophiles occurs at the #x1B;(Sd#x1B;(B-position of the propargyl sulfones with 1,2-sulfonyl migration. The resulting oxa- and azacycles are core structures in many biologically significant compounds and medicinally important agents. In addition, the book develops the chiral NHC-catalyzed kinetic resolution of #x1B;(Sa#x1B;(B-hydroxy carboxylic acid derivatives based on chiral recognition of the substrate-cocatalyst complex. In this carboxylate cocatalyst-assisted chiral acylation, the reaction rate acceleration and selectivity enhancement are interpreted in terms of the reversible complexation of the substrate and carboxylate cocatalyst, which is verified by control experiments and measured using analytical methods. The findings described here reveal a promising new aspect of not only NHC catalysis but also identifying novel catalysis systems.

منبع سفارش / آدرس اشتراک

Springer Nature

شماره انبار

com.springer.onix.9789811393983

عنوان

Development of a New Heterocycle-Forming Reaction and Kinetic Resolution with N-Heterocyclic Carbenes.

شماره استاندارد بين المللي کتاب و موسيقي

9789811393976

موضوع مستند نشده

Carbenes (Methylene compounds)

موضوع مستند نشده

Heterocyclic chemistry.

موضوع مستند نشده

Carbenes (Methylene compounds)

موضوع مستند نشده

Heterocyclic chemistry.

موضوع مستند نشده

PNN

موضوع مستند نشده

PNN

موضوع مستند نشده

SCI013040

شماره

شماره

ويراست

شماره رده

شماره رده

مستند نام اشخاص تاييد نشده

Wang, Yinli.

تاريخ عمليات

20200823231509.0

قواعد فهرست نويسي ( بخش توصيفي )

pn

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y