عنوان

Quantification of circulating proteins :

شابک

9400976607

شابک

9789400976603

شماره

b593870

عنوان اصلي

Quantification of circulating proteins :

نام عام مواد

[Book]

ساير اطلاعات عنواني

theory and applications based on analysis of plasma protein levels

نام نخستين پديدآور

by Wim Th. Hermens, George M. Willems, Marja P. Visser.

محل نشرو پخش و غیره

The Hague

نام ناشر، پخش کننده و غيره

Netherlands Martinus Nijhoff

تاریخ نشرو بخش و غیره

1982. ©1982

نام خاص و کميت اثر

(264p.)

متن يادداشت

1: Introduction --; 1.1 Quantitative description of circulating proteins --; 1.2 Presentation of theory and applications --; A: Physiological basis, choice of models and quantitative methods --; 2: Turnover and distribution of circulating tissue enzymes --; 3: Turnover and distribution of plasma proteins --; 4: Methods and models used in quantitative studies of circulating proteins --; 5: Sources of error in quantification of circulating proteins --; B : Applications --; 6: Assessment of myocardial damage from plasma levels of cardiac enzymes --; 7: Changes in circulating mass of plasma proteins during the acute phase response --; 8: Dose-calculation of blood coagulation factors for infusion therapy --; 9: A review of data on the turnover and distribution of circulating proteins --; Appendix: Derivation of mathematical expressions --; References.

متن يادداشت

Less than 50 years ago it was discovered that steady-state protein concentrations in plasma are the net result of continuous elimination and synthesis of protein molecules. The first quanti­ tative studies on the turnover and distribution of plasma pro­ teins were made around 1950, after the introduction of radio­ labeled protein preparations. Around 1970, another development in quantitative interpre­ tation of circulating proteins was initiated in clinical enzy­ mology. Estimation of cumulative release into plasma of cellular enzymes can be helpful in a variety of diseases to assess the extent of tissue damage and to evaluate therapy. Enzymes can be considered as biological tracers, i.e. minute quantities of protein can be accurately determined by their spe­ cific catalytic activities. However, radioactive tracers permit direct estimates of turnover and distr ibution by measurement of excreted radioactivity, possibilities that are not available for enzymes. Consequently, only a few techniques used in tracer studies with radiolabeled proteins can be applied to circulating tissue enzymes and this may explain the lack of communication between the fields of plasma protein metabolism and quantitative clinical enzymology. In the present study a summary is given of the basic methods used in both fields, with emphasis on the equivalence of various models and formalisms used by different authors. It is shown that major limitations in the study of circulating tissue enzymes can be overcome if two different, but simultaneously released, en­ zymes can be measured. The resulting method will also be applied to plasma protein metabolism.

موضوع مستند نشده

Blood proteins -- Analysis.

موضوع مستند نشده

Blood proteins -- Metabolism.

موضوع مستند نشده

Medicine & Public Health.

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

by Wim Th. Hermens, George M. Willems, Marja P. Visser.

مستند نام اشخاص تاييد نشده

George M Willems

مستند نام اشخاص تاييد نشده

Marja P Visser

مستند نام اشخاص تاييد نشده

Wim Th Hermens

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y