عنوان

Role of pharmacology in pediatric oncology.

شابک

9400942672

شابک

9789400942677

شماره

b593305

عنوان اصلي

Role of pharmacology in pediatric oncology.

نام عام مواد

[Book]

محل نشرو پخش و غیره

[Place of publication not identified]

نام ناشر، پخش کننده و غيره

Springer

تاریخ نشرو بخش و غیره

2013

متن يادداشت

Principles of Antineoplastic Therapy in Children.- 1. Clinical pharmacokinetics for the pediatric oncologist.- 2. The pharmacology of antineoplastic agents in children.- 3. Clinical pharmacology of anticancer drugs in children: differences and similarities between children and adults.- Pharmacologic reasons for treatment failure.- 4. Drug resistance in medical and pediatric oncology.- 5. Genetic reasons for pharmacologic treatment failure: gene amplification.- 6. New approaches to overcome drug resistance.- Methods of drug delivery.- 7. New methods of administering old drugs: iv infusion of mercaptopurine.- 8. Regional therapy: an overview.- 9. Pharmacologic approaches to the treatment of central nervous system malignancy.- Use of new agents in children.- 10. Phase I and II trials in pediatric cancer patients: a rationale.- 11. Guidelines for conduct of Phase I studies in children.- Pharmacology of antileukemic agents.- 12. Factors affecting the clinical pharmacology of antileukemic drugs.- 13. Potentiation of 6-mercaptopurine after time and dose-dependent pretreatment with methotrexate in malignant human T- and B-lymphoblasts.- 14. The effect of methotrexate on purine and pyrimidine deoxyribonucleoside triphosphate pools and on cell viability and cell-phase distribution in malignant human T- and B-lymphoblasts.- 15. 7-Hydroxy-methotrexate production after methotrexate therapy.- Late effects of chemotherapy.- 16. An overview of adverse late effects of cancer chemotherapy in children.- 17. Focusing on late effects in long-term survivors of childhood leukemia and lymphomas.- High dose chemotherapy.- 18. Purging procedures: a critical step in autologous bone marrow transplantation.- 19. `High dose' cisplatinum: a phase II study.- Biological response modifiers.- 20. Induction of differentiation: a possible therapeutic approach to the treatment of hematologic malignancy.- 21. The development of 9-substituted purines as immunomodulators.- 22. Immunopharmacologic profile of an L-Arginine hypoxanthine dervative: PCF/01.- 23. Antineoplastic drugs modulating c-myc expression in K562, induce erythroid differentiation and modify, with IFN, susceptibility to NK cell mediated lysis.- 24. In vivo treatment with recombinant interleukin-2 (IL-2) stimulates the differentiation of natural killer (NK) precursor cells.- 25. Immunopharmacology studies related to in vitro infection with HTLV-I.

شماره رده

نشانه اثر

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y