عنوان

Risk and Progression Factors in Carcinogenesis

شابک

3540609539

شابک

3642603939

شابک

9783540609537

شابک

9783642603938

شماره

b571979

عنوان اصلي

Risk and Progression Factors in Carcinogenesis

نام عام مواد

[Book]

نام نخستين پديدآور

edited by H.K. Müller-Hermelink, H.-G. Neumann, W. Dekant.

محل نشرو پخش و غیره

Berlin, Heidelberg

نام ناشر، پخش کننده و غيره

Springer Berlin Heidelberg

تاریخ نشرو بخش و غیره

1997

نام خاص و کميت اثر

(xii, 394 pages 129 illustrations)

عنوان فروست

Recent results in cancer research, 143.

متن يادداشت

I. Interaction of Carcinogens with Cellular DNA --; Induction of Frameshift Mutations at Hotspot Sequences by Carcinogen Adducts --; Oxidative DNA Damage Induced by Dioxetanes, Photosensitizing Ketones, and Photo-Fenton Reagents --; Oxidative DNA Damage Profiles in Mammalian Cells --; Chemical Mechanisms of Formation of DNA-Carcinogen Adducts, Elucidation of Potential of Adducts for Mutagenicity, and Mechanisms of Polymerase Fidelity and Mutation in the Presence of Adducts --; Assessment of the Tumor-Initiating Potential of?,?-Unsaturated Carbonyl Compounds by 32P Postlabeling Quantification of DNA Adducts In Vivo --; Glutathione-Dependent Bioactivation and Renal Toxicity of Xenobiotics --; Ultraviolet-Induced Photolesions: Repair and Mutagenesis --; Psoralen Photobiology: The Relationship Between DNA Damage, Chromatin Structure, Transcription, and Immunogenic Effects --; II. Analysis of Cellular Alterations and Growth Dysregulation in Cancer Cells --; Cellular Stress Response: Stress Proteins --; Physiology and Implications for Cancer --; Two-Dimensional Polyacrylamide Gel Electrophoresis of Cancer-Associated Proteins --; Mechanisms Leading to the Expression of Recessive Alleles: The Use of Polymorphic Microsatellites and Whole-Chromosome Painting Probes to Analyze Mouse Tumors, Mtants, and Micronuclei --; Formation of Micronuclei and Inhibition of Topoisomerase II in the Comet Assay in Mammalian Cells with Altered DNA Methylation --; Poly(ADP-Ribosyl)ation and Nuclear Matrix/Intermediate Filament Proteins in Renal Carcinogenesis --; Genotoxic and Chronic Toxic Effects in the Carcinogenicity of Aromatic Amines --; Analysis of Genetic Factors and Molecular Mechanisms in the Development of Hereditary and Carcinogen-Induced Tumors of Xiphophorus --; The Role of Raf Kinases in Development and Growth of Tumors --; Apoptosis Regulation by Raf, Bcl-2, R-Ras --; New Cell Cycle-Regulated Genes in the Yeast Saccharomyces cerevisiae --; The Role of Workhorse Protein Kinases in Coordinating DNA Metabolism and Cell Growth --; III. Selected Findings in Human Tumors --; Growth and Transformation of Human Oral Epithelium In Vitro --; Genetic Lesions in Mantle Cell Lymphoma --; Topoisomerase Activities in Undifferentiated Acute Myeloblastic Leukemias and Monocytic Differentiated Leukemias --; DNA Repair: Genes, Enzymes, Patients, and Mouse Models --; Repair of Directly and Indirectly UV-Induced DNA Lesions and of DNA Double-Strand Breaks in Cells from Skin Cancer-Prone Patients with the Disorders Dysplastic Nevus Syndrome or Basal Cell Nevus Syndrome --; Exploring the Role of Oxygen in Fanconis Anemia --; P53 Gene Alterations in Human Tumors: Perspectives for Cancer Control.

متن يادداشت

The principal goal of experimental carcinogenesis is the elucidation of mechanisms and factors that might be of relevance for the formation of human tumors. Specialization, as necessary as it may be, however, may prevent the transfer of knowledge among disciplines involved in cancer research. Leading scientists give insight into mechanisms of carcinogen-induced DNA damage and mutagenicity, and cellular responses including DNA repair, cellular stress, apoptosis, and regulation of cellular growth. Selected human tumor models of oral epithelium, skin cancer, and malignant lymphoma are analyzed in order to determine the most relevant primary genetic alteration in cell-specific transformation. Finally, the epidemiology of p53 mutation is considered as an indication of specific pathogenetic factors in sporadic human tumors.

موضوع مستند نشده

Cell Transformation, Neoplastic.

موضوع مستند نشده

Medicine.

موضوع مستند نشده

Oncology.

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

edited by H.K. Müller-Hermelink, H.-G. Neumann, W. Dekant.

مستند نام اشخاص تاييد نشده

H K Müller-Hermelink

مستند نام اشخاص تاييد نشده

H -G Neumann

مستند نام اشخاص تاييد نشده

W Dekant

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y