عنوان

Prodrugs and Targeted Delivery :

شابک

1283140578

شابک

3527326030

شابک

3527633162

شابک

3527633170

شابک

9781283140577

شابک

9783527326037

شابک

9783527633166

شابک

9783527633173

شماره

b563730

عنوان اصلي

Prodrugs and Targeted Delivery :

نام عام مواد

[Book]

ساير اطلاعات عنواني

Towards Better ADME Properties.

نام نخستين پديدآور

Jarkko Rautio

محل نشرو پخش و غیره

Weinheim

نام ناشر، پخش کننده و غيره

Wiley-VCH

تاریخ نشرو بخش و غیره

©2011.

نام خاص و کميت اثر

(522 pages)

عنوان فروست

Methods and principles in medicinal chemistry.

متن يادداشت

Front Matter --; Prodrug Design and Intellectual Property. Prodrug Strategies in Drug Design / Jarkko Rautio --; The Molecular Design of Prodrugs by Functional Group / Victor R Guarino --; Intellectual Property Primer on Pharmaceutical Patents with a Special Emphasis on Prodrugs and Metabolites / Eyal H Barash --; Prodrugs Addressing ADMET Issues. Increasing Lipophilicity for Oral Drug Delivery / Majid Y Moridani --; Modulating Solubility Through Prodrugs for Oral and IV Drug Delivery / Victor R Guarino --; Prodrugs Designed to Target Transporters for Oral Drug Delivery / Mark S Warren, Jarkko Rautio --; Topical and Transdermal Delivery Using Prodrugs: Mechanism of Enhancement / Kenneth Sloan, Scott C Wasdo, Susruta Majumdar --; Ocular Delivery Using Prodrugs / Deep Kwatra, Ravi Vaishya, Ripal Gaudana, Jwala Jwala, Ashim K Mitra --; Reducing Presystemic Drug Metabolism / Majid Y Moridani --; Enzyme-Activated Prodrug Strategies for Site-Selective Drug Delivery / Krista Laine, Kristiina Huttunen --; Prodrug Approaches for Central Nervous System Delivery / Quentin R Smith, Paul R Lockman --; Directed Enzyme Prodrug Therapies / Dan Niculescu-Duvaz, Gabriel Negoita-Giras, Ion Niculescu-Duvaz, Douglas Hedley, Caroline J Springer --; Codrugs and Soft Drugs. Improving the Use of Drug Combinations Through the Codrug Approach / Peter A Crooks, Harpreet K Dhooper, Ujjwal Chakraborty --; Soft Drugs / Paul W Erhardt, Michael D Reese --; Preclinical and Clinical Consideration for Prodrugs. Pharmacokinetic and Biopharmaceutical Considerations in Prodrug Discovery and Development / John P O'Donnell --; The Impact of Pharmacogenetics on the Clinical Outcomes of Prodrugs / Jane P F Bai, Mike Pacanowski, Atiqur Rahman, Lawrence L Lesko --; Index. Prodrugs and Targeted Delivery: Towards Better ADME Properties; Contents; List of Contributors; Preface; A Personal Foreword; Part One: Prodrug Design and Intellectual Property; 1 Prodrug Strategies in Drug Design; 2 The Molecular Design of Prodrugs by Functional Group; 3 Intellectual Property Primer on Pharmaceutical Patents with a Special Emphasis on Prodrugs and Metabolites; Part Two: Prodrugs Addressing ADMET Issues; 4 Increasing Lipophilicity for Oral Drug Delivery; 5 Modulating Solubility Through Prodrugs for Oral and IV Drug Delivery. 6 Prodrugs Designed to Target Transporters for Oral Drug Delivery7 Topical and Transdermal Delivery Using Prodrugs: Mechanism of Enhancement; 8 Ocular Delivery Using Prodrugs; 9 Reducing Presystemic Drug Metabolism; 10 Enzyme-Activated Prodrug Strategies for Site-Selective Drug Delivery; 11 Prodrug Approaches for Central Nervous System Delivery; 12 Directed Enzyme Prodrug Therapies; Part Three: Codrugs and Soft Drugs; 13 Improving the Use of Drug Combinations Through the Codrug Approach; 14 Soft Drugs; Part Four: Preclinical and Clinical Consideration for Prodrugs. 15 Pharmacokinetic and Biopharmaceutical Considerations in Prodrug Discovery and Development16 The Impact of Pharmacogenetics on the Clinical Outcomes of Prodrugs; Index.

متن يادداشت

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.

موضوع مستند نشده

Medicine.

موضوع مستند نشده

Pharmacy.

موضوع مستند نشده

Prodrugs.

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

Jarkko Rautio

مستند نام اشخاص تاييد نشده

Hugo Kubinyi

مستند نام اشخاص تاييد نشده

Jarkko Rautio

مستند نام اشخاص تاييد نشده

Raimund Mannhold

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y