عنوان

Synthesis of Novel Thiazole and Pyrazole Derivatives as Antimicrobial and Anticancer Agents

Number

TLpq2447299030

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

Synthesis of Novel Thiazole and Pyrazole Derivatives as Antimicrobial and Anticancer Agents

General Material Designation

[Thesis]

First Statement of Responsibility

Khan, Md Mahbub Kabir

Subsequent Statement of Responsibility

Alam, Mohammad A.

Name of Publisher, Distributor, etc.

Arkansas State University

Date of Publication, Distribution, etc.

2020

Specific Material Designation and Extent of Item

204

Dissertation or thesis details and type of degree

M.S.

Body granting the degree

Arkansas State University

Text preceding or following the note

2020

Text of Note

This thesis contains two chapters. In chapter one, I report the synthesis of new pyrazole derivatives from dicarboxylic acid containing phenyl-derived, monotrifluoromethyl phenyl-derived, and acetovanillone-derived pyrazole aldehydes using Hantzsch ester. All of our pyrazole compounds have been synthesized efficiently using Hantzsch ester without any catalyst. Most of our pyrazole and thiazole compounds have been effectively recrystallized with acetonitrile and methanol respectively. We have synthesized 99 different pyrazole, 17 fused-thiazole ethisterone, and D-(-) norgestrel derivatives in good yield. In the present research, it has been shown possible to synthesize novel pyrazoles and thiazoles by using readily available starting materials and benign reaction conditions. Most of our compounds showed promising activity against several Gram-positive bacterial strains. All of these pyrazole and thiazole molecules have been identified by 1H NMR and 13C NMR spectroscopy and chemical structures have been confirmed by High Resolution Mass Spectrometry (HRMS).

Chemistry

Organic chemistry

Alam, Mohammad A.

Khan, Md Mahbub Kabir

Electronic name

p

[Thesis]

276903

a

Y