عنوان

Antibiotic Use in Hospitalized Children: Current Practices and the Impact of Virus Diagnostic Testing on Antibiotic-Related Decisions

Number

TL53849

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

Antibiotic Use in Hospitalized Children: Current Practices and the Impact of Virus Diagnostic Testing on Antibiotic-Related Decisions

General Material Designation

[Thesis]

First Statement of Responsibility

Noël, Kim Chloé

Subsequent Statement of Responsibility

Fontela, Patricia

Name of Publisher, Distributor, etc.

McGill University (Canada)

Date of Publication, Distribution, etc.

2019

Text of Note

150 p.

Dissertation or thesis details and type of degree

M.S.

Body granting the degree

McGill University (Canada)

Text preceding or following the note

2019

Text of Note

Antibiotic overuse and bacterial resistance are major public health threats. This problem is particularly important in the hospital setting, especially in intensive care units. Factors contributing to antibiotic overuse are the lack of evidence-based criteria to guide antibiotic treatment duration for patients with bacterial infections, and the difficulty in differentiating between viral and bacterial acute respiratory infections (ARIs). It is currently unclear which criteria physicians use to tailor the duration of antibiotic therapy. We hypothesized that antibiotic use in pediatric intensive care units (PICUs) is based on criteria not always supported by evidence. Our first objective was therefore to describe the determinants of antibiotic use in PICUs across eight countries (Canada, the US, Saudi Arabia, Italy, Thailand, France, Japan, and Brazil). Our international survey results showed that physicians in all countries would prolong antibiotic duration based on patient characteristics, disease severity, pathogens, and infectious radiologic findings, ranging from a median increase of 1.75 (95% confidence interval [CI] 0.5, 4.0) to 9.5 (95%CI 8.5, 10.5) days. Importantly, physicians would prolong treatment duration based on non-reassuring characteristics including younger age, severe disease, and hospital-acquired infections, even if current literature does not support the use of these criteria. Physicians in Saudi Arabia, Thailand, and Brazil would recommend longer antibiotic courses than in Canada and France for patients with severe disease. Lastly, we found that a high proportion of physicians would still use a full course of antibiotics in patients with a positive viral test result, except in France, suggesting that local culture and context may influence the clinical utility of viral tests. Another factor driving antibiotic overuse in hospitalized children is the frequent use of antibiotics for viral ARIs, as viral and bacterial ARIs are often clinically indistinguishable. Respiratory virus (RV) diagnostic tests are commonly used in children hospitalized with ARI, but current literature regarding their clinical utility to reduce antibiotic use is conflicting. We hypothesized that the use of RV tests decreases unnecessary antibiotic use in this patient population. Our second objective was therefore to conduct a systematic review and meta-analysis to determine the impact of RV testing on antibiotic consumption, as well as on the use of ancillary testing, length of hospital stay, and use of influenza antivirals in children hospitalized with ARI. We included 23 studies, of which 19 (83%) were at serious risk of bias. Pooled results showed no difference in antibiotic prescription between patients with a positive vs. negative RV test result (odds ratio [OR] 0.84; 95% confidence interval [CI] 0.65,1.09). Analysis stratified by study design showed that RV testing decreased antibiotic use in prospective cohort studies (OR 0.58; 95%CI 0.45, 0.75). Pooled results showed no impact on use of chest x-rays (OR 0.71; 95%CI 0.48, 1.04). In conclusion, this thesis identified several antibiotic practices that may be associated with unnecessary antibiotic use in pediatric patients. We showed that physicians tend to overuse antibiotics by prolonging treatment duration in the face of non-reassuring clinical characteristics. In addition, while our meta-analysis did not find an impact of viral testing on antibiotic use, our survey showed that such tests may potentially be clinically useful depending on the local culture and context. Importantly, our results support the need for validated and evidence-based criteria to diagnose infections and guide treatment duration, in order to reduce unnecessary exposure to antibiotics in hospitalized children.

Subject Term

Medicine

Subject Term

Virology

Noël, Kim Chloé

Fontela, Patricia

McGill University (Canada)

Electronic name

p

[Thesis]

276903

a

Y