Front Cover; Advances in Immunology, Volume 52; Copyright Page; Contents; Chapter 1. Cell Biology of Antigen Processing and Presentation to Major Histocompatibility Complex Class I Molecule-Restricte T Lymphocytes; I. Introduction; II. Antigen Processing; III. Properties of Cell Surface Class I Molecules; IV. Class Ib Molecules; V. Practical and Evolutionary Considerations; References; Chapter 2. Human B Lymphocytes: Phenotype, Proliferation, and Differentiation; I. Introduction; II. Phenotype of B Lymphocytes; III. Cytokines Involved in B Cell Growth and Differentiation.
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III. Regulatory DNA Sequences in Type I Interferon GenesIV. Transcription Factors That Bind to Regulatory Elements of Type I Interferon Genes; V. Transcriptional Regulation of Interferon-Inducible Genes: Potential Role of IRF-1 and IRF-2; VI. Conclusions; References; Chapter 4. Cellular and Molecular Mechanisms of B Lymphocyte Tolerance; I. Introduction; II. Early Tolerance Studies Affecting Antibody Formation; III. Antigen Polymerization and B Cell Tolerance; IV. B Cell Maturity and Tolerance; V. Biochemical Basis of B Cell Tolerance; VI. Transgenic Approaches to B Cell Tolerance.
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IV. Negative Regulators of Growth and Differentiation of Human Basophils and Human Mast CellsV. Adhesion Receptors and Recognition Molecules; VI. Receptors for Activating Peptides; VII. Complement Binding Sites; VIII. Immunoglobulin Receptors; IX. Receptors for Low-Molecular-Weight Regulators and Pharmacological Compounds; X. Concluding Remarks; References; Chapter 6. Animal Models for Acquired Immunodeficiency Syndrome; I. Introduction; II. Relationships among the Viruses Used as Animal Models for AIDS; III. Models Using Viruses Distantly Related to HIV-1.
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IV. Polyclonal Activation of Human B CellsV. Cytokines and B Lymphocyte Growth; VI. Cytokines and B Lymphocyte Differentiation; VII. Role of Complement in B Cell Growth and Differentiation; VIII. Autocrine Aspects of B Cell Growth and Differentiation; IX. In Vivo Aspects of B Cell Growth and Differentiation; X. Concluding Remarks: Human B Cells in the Year 2000; References; Note Added in Proof; Chapter 3. Cytokine Gene Regulation: Regulatory cis-Elements and DNA Binding Factors Involved in the Interferon System; I. Introduction; II. The Interferon System.
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VII. B Cell Tolerance in the Secondary RepertoireVIII. Other Perspectives in Tolerance Including Antigen Presentation by B Cells; IX. Resolution of Apparently Conflicting Models of B Cell Tolerance; X. Summary and Conclusions; References; Chapter 5. Cell Surface Structures on Human Basophils and Mast Cells: Biochemical and Functional Characterization; I. Introduction; II. The CD Nomenclature: Cell Surface Typing with Monoclonal Antibodies-Immunophenotypic Characterization of Human Mast Cells and Basophils; III. Receptors for Growth and Differentiation Factors.