عنوان

Handbook on syntheses of amino acids :

(Number (ISBN

0841272190

(Number (ISBN

9780841272194

Number

b724093

Title Proper

Handbook on syntheses of amino acids :

General Material Designation

[Book]

Other Title Information

general routes for the syntheses of amino acids /

First Statement of Responsibility

Mark A. Blaskovich.

Place of Publication, Distribution, etc.

New York :

Name of Publisher, Distributor, etc.

Oxford University Press,

Date of Publication, Distribution, etc.

2010.

Specific Material Designation and Extent of Item

xvii, 1305 pages :

Other Physical Details

illustrations ;

Dimensions

26 cm

Text of Note

Includes bibliographical references and index.

Text of Note

Synthesis of Racemic a-Amino Acids: Amination and Carboxylation -- Synthesis of Racemic -Amino Acids: Introduction of the Side Chain -- Synthesis and Elaboration of Didehydro Amino Acids -- Synthesis of Optically Active a-Amino Acids: Extension of Achiral Methods -- Amination and Carboxylation Reactions -- Synthesis of Optically Active Amino Acids: Extension of Achiral Methods -- Introduction fo the Side Chain to Acyclic Systems -- Synthesis of Optically Active a-Amino Acids: Alkylation of Cyclic Chiral Templates -- Synthesis of Optically Active a-Amino Acids: Opening of Small Ring Systems -- Synthesis of Optically Active a-Amino Acids: Elaboration of Amino Acids Other than Serine -- Synthesis of Optically Active -Amino Acids: Elaboration of Serine -- Synthesis of -, -, -, and -Amino Acids -- Modifications of Amino Acids: Resolution, N-Alkylation, N-Protection, Amidation and Coupling.

0

Text of Note

"Amino acid synthesis is a field of research that has existed for over 150 years, but renewed interest has led to an exponential increase in publications in the past two decades. The Handbook on Syntheses of Amino Acids provides a comprehensive survey of synthetic procedures that prepare natural and unnatural amino acids in both racemic and optically active forms. The book begins with an introduction to amino acids, their properties, and analytical techniques, including a detailed examination of methods used to establish enantiomeric configuration and optical purity. The next two chapters focus on processes for preparing racemic amino acids, divided into those syntheses that introduce the amino and/or carboxy groups, and those that introduce the side chain. While some of these procedures date from the 1800s, modified versions are still extensively employed. A key component of these chapters is tables that summarize the many compounds made by each method. A chapter devoted to 2,3-dehydroamino acids provides the bridge between racemic and asymmetric syntheses, as dehydroamino acids are themselves achiral, but can be transformed into optically active products. Asymmetric amino acid preparations are then divided into six chapters, based on methods that introduce the amino and/or carboxy groups, those that introduce the side chains to acyclic synthons, those that introduce side chain to cyclic templates, those that open small ring systems, and those that derive the amino acid from other amino acids (with a separate chapter for serine-derived products). The growing field of non-alpha-amino acid synthesis is addressed in a separate chapter . The book is completed by a discussion of amino acid modifications, including resolutions, N-alkylations, amidations and peptide couplings."--Publisher's website.

Amino acids-- Synthesis.

Amino Acids.

Amino acids-- Synthesis.

Aminosäuren.

Chemische Synthese.

Number

Edition

Class number

Book number

Class number

Blaskovich, Mark A.

Date of Transaction

20201209181954.0

Electronic name

[Book]

Y