Structure prediction and binding site identification of the CD28 and B7 family molecules / Jürgen Bajorath -- T-lymphocyte signaling pathways regulated by CD28 and CTLA-4 / David J. McKean and Matthew D. Griffin -- Costimulatory molecules in T-cell development, activation and effector function / Yang Liu [and others] -- Negative costimulatory functions of B7-H1 / Haidong Dong [and others] -- PD-1 / Gordon J. Freeman and Arlene H. Sharpe -- The ICOS/B7RP-1 costimulation pathway / Steven K. Yoshinaga -- Role of ICOS in T-cell activation / Jeffrey A. Ledbetter, Erik Espling and Martha Hayden-Ledbetter -- B7-H3 / Andrei I. Chapoval and Lieping Chen -- The role of B7s in transplantation / Didier A. Mandelbrot [and others] -- B7 family of costimulatory molecules in the induction and regulation of autoimmunity / Claudia Jabs, Arlene H. Sharpe and Vijay K. Kuchroo -- Operation enduring costimulation / Eugene D. Kwon, Qingyong Ji and Arthur A. Hurwitz.