A diagnostically challenging case of CD8+ primary cutaneous gamma/delta T-cell lymphoma
General Material Designation
[Article]
First Statement of Responsibility
Pitch, Michelle A; Kim, Kevin H; Manning, Trey; Smoller, Bruce R; Wong, Henry K; Kaley, Jennifer R
SUMMARY OR ABSTRACT
Text of Note
Primary cutaneous gamma/delta T-cell lymphoma (PCγδTCL) is a rare form of cutaneous lymphoma characterized by abnormal clonal proliferation of mature, activated gamma-delta T cells expressing the γδ heterodimer of the T-cell receptor (TCR). As an entity, PCγδTCL has recently undergone diagnostic revision since its introduction in the 2008 WHO classification of cutaneous lymphomas and confirmedin 2016. Nonetheless, diagnosis remains difficult both clinically and histologically, given its broad range of clinical manifestations and immunohistochemical phenotypes. Herein, we present a rare case of CD8+ PCγδTCL with a discussion highlighting theheterogeneity within this entity.
SET
Date of Publication
2017
Title
Dermatology Online Journal
Volume Number
23/11
PERSONAL NAME - PRIMARY RESPONSIBILITY
Entry Element
Pitch, Michelle A; Kim, Kevin H; Manning, Trey; Smoller, Bruce R; Wong, Henry K; Kaley, Jennifer R