Mohammad A. Tabrizi, Gadi G. Bornstein, Scott L. Klakamp, editors.
EDITION STATEMENT
Edition Statement
Second edition.
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Singapore :
Name of Publisher, Distributor, etc.
Adis,
Date of Publication, Distribution, etc.
[2018]
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
1 online resource
INTERNAL BIBLIOGRAPHIES/INDEXES NOTE
Text of Note
Includes bibliographical references.
CONTENTS NOTE
Text of Note
Introduction -- Translational considerations and challenges : an overview -- Considerations for construct and affinity design goals -- Epitope characterization and isotype selection -- Biophysical considerations for development of antibody-based therapeutics -- Novel technologies for generation of bispecific constructs -- Stimulus-response mechanisms : an overview -- Evaluation of tumor growth inhibition in preclinical tumor models : a quantitative approach -- Application of proof-of-mechanism biomarkers (POM) in design and development of biologics modalities -- Antibody drug conjugates : translational considerations -- Application of PK-PD modeling and simulation approaches for immuno-oncology drugs -- Translational biomarkers : application in the clinical development of combination therapies -- Correction to : considerations for construct and affinity design goals.
0
SUMMARY OR ABSTRACT
Text of Note
This book examines vital considerations in designing effective translational strategies in the development of antibody-based therapeutics, including the relationship between the 'unit dose' and 'unit effect' with respect to beneficial and deleterious effects.