عنوان

Precision molecular pathology of neoplastic pediatric diseases /

(Number (ISBN

3030078183

(Number (ISBN

3319896261

(Number (ISBN

331989627X

(Number (ISBN

9783030078188

(Number (ISBN

9783319896267

(Number (ISBN

9783319896274

Erroneous ISBN

3319896253

Erroneous ISBN

9783319896250

Title Proper

Precision molecular pathology of neoplastic pediatric diseases /

General Material Designation

[Book]

First Statement of Responsibility

Larissa V. Furtado, Aliya N. Husain, editors.

Place of Publication, Distribution, etc.

Cham, Switzerland :

Name of Publisher, Distributor, etc.

Springer,

Date of Publication, Distribution, etc.

2018.

Specific Material Designation and Extent of Item

1 online resource

Series Title

Molecular pathology library,

ISSN of Series

1935-987X

Text of Note

Includes index.

Text of Note

Intro; Contents; Contributors; Part I: Molecular Pathology of Pediatric Neoplasms: General Principles; Chapter 1: Principles of Molecular Biology and Oncogenesis; Principles of Molecular Biology; Nucleic Acid Structure, Composition, and Organization; Gene Structure, Organization, and Expression; Chromosome Structure; Mitochondrial DNA; Principles of Oncogenesis; Oncogenes; Tumor Suppressor Genes; References; Chapter 2: Molecular Methods in Oncology: Targeted Mutational Analysis; PCR-Based Techniques; Overview; Background; Method; Template; Primers; Polymerase; Procedure.

Text of Note

Advantages/DisadvantagesAdvantages; Disadvantages; Applications; Variations; Reverse Transcriptase PCR (RT-PCR); Real-Time PCR/Quantitative PCR (qPCR); Nested PCR; Multiplex PCR; Allele-Specific PCR (ASPCR); Digital PCR (dPCR); Methylation-Specific PCR; Fluorescence In Situ Hybridization (FISH); Overview; Background; Method; Probes; Targets; Procedure; Signals and Detection; Advantages and Disadvantages; Advantages; Disadvantages; Applications; Chromosomal Aneusomies; Segmental Deletions; Single Gene Amplification; Translocations; Other Clinically Relevant FISH Variants; References.

Text of Note

Chapter 3: Molecular Methods in Oncology: Genomic AnalysisNext-Generation Sequencing; Overview; Background; Methods; Next-Generation Sequencing (NGS); Solexa/Illumina; Ion Semiconductor Sequencing; Single-Molecule Real-Time (SMRT) Sequencing; Sequencing by Oligonucleotide Ligation and Detection (SOLiD); Data Analysis; Applications; Chromosomal Microarray; Overview; Background; Methods; General Principles; Comparative Genomic Hybridization (CGH); DNA Sequence Analysis; Gene Expression Profiling; Advantages and Disadvantages; Applications; References.

Text of Note

Chapter 4: Molecular Testing in Pediatric Oncology PracticeIntroduction; Indications for Molecular Testing; Diagnosis; Prognosis; Therapeutic Guidance; Disease Status Monitoring; Inherited Susceptibility; Specimens for Molecular Testing; Peripheral Blood; Bone Marrow; Tissue; Cytology Specimens; Acellular Body Fluids; Buccal Swab/Saliva; Skin/Fibroblast Culture; Specimen Collection/Handling Procedures; Selecting the Appropriate Molecular Test; What Is the Test Purpose?; What Are the Possible Specimen Options?; What Are the Available Test Options?

Text of Note

How Does the Clinical Scenario Impact the Decision?Interpretation and Integration of Test Results; Ethical Considerations in Pediatric Genomic Oncology Testing; References; Chapter 5: Molecular Targeted Therapy of Pediatric Neoplasms; Introduction; Mechanisms to Identify Potential Targets; Mechanisms to Target Cancer Cells; Metabolic Differences; Asparaginase; Methotrexate; DFMO; Aberrant Signaling; Tyrosine Kinase Inhibitors; Imatinib, Dasatinib; Ruxolitinib; Pazopanib; WEE1 Inhibitor; Serine/Threonine Kinase Inhibitors; Everolimus; Temsirolimus; Targeting Restricted Protein Expression.

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8

8

8

8

Text of Note

This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their molecular pathogenesis, clinicopathological features, classification, molecular diagnosis, and approaches to personalized care. Written by experts in the field, Precision Molecular Pathology of Neoplastic Pediatric Diseases serves as a valuable resource for pathologists, pediatric oncologists, trainees and researchers with an interest in pediatric and molecular pathology.

Source for Acquisition/Subscription Address

Springer Nature

Stock Number

com.springer.onix.9783319896267

Title

Precision molecular pathology of neoplastic pediatric diseases.

International Standard Book Number

9783319896250

Tumors in children-- Molecular aspects.

HEALTH & FITNESS-- Diseases-- General.

MEDICAL-- Clinical Medicine.

MEDICAL-- Diseases.

MEDICAL-- Evidence-Based Medicine.

MEDICAL-- Internal Medicine.

Medicine.

Oncology.

Oncology.

Pathology.

Pathology.

HEA-- 039000

MED-- 014000

MED-- 022000

MED-- 045000

MED-- 112000

MKF

MMF

Number

Edition

Class number

Furtado, Larissa V.

Husain, Aliya N.

Date of Transaction

20200823114611.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y