Intro; "Resistance to Targeted Anti-Cancer Therapeutics": Aims and Scope; Preface; Biography of Series Editor; Acknowledgments; Contents; Clinical Use and Efficacy of Ibritumomab in B Cell Lymphoma; 1 Introduction; 2 Characteristics of Zevalin; 3 Treatment Schedule and Dosage of Zevalin; 4 Patient Eligibility; 5 Zevalin in Relapse or Refractory Patients; 6 Zevalin in Frontline Therapy; 7 Toxicities and Safety Profile; 8 Factor Associated with Effects of Zevalin; 9 Future Aspects; References; Biology and Pathology of B-Cell Lymphoma; 1 Introduction; 2 Cellular Origin of B-Cell Lymphomas.
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3 Features of Ibritumomab4 A Model of Theranostic Approach; 5 Enhancing Efficacy of Ibritumomab Tiuxetan; 6 Conclusion; References; Radiological Evaluation of Response and Resistance of Ibritumomab; 1 Introduction; 2 Evaluation of FDG-PET/CT for Monitoring the Response to RIT; 2.1 FDG-PET/CT Imaging; 3 Summary of the Results; 4 Discussion; 5 Conclusions; References; Characteristics of Ibritumomab as Radionuclide Therapy Agent; 1 Introduction; 2 CD 20: B-Cell Antigen; 3 mAb Targeting CD20; 4 Ibritumomab Tiuxetan Coupled with Radioisotopes; 4.1 Ibritumomab; 4.2 Tiuxetan; 4.3 Radionuclides.
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5 Conclusions and PerspectivesReferences; Radiation Dosimetry in Ibritumomab Therapy; 1 Introduction; 2 Activity Escalation Trial and Dose Escalation Trial; 3 Dosimetry for Molecular Radiotherapy; 3.1 Quantification of Pharmacokinetics; 3.2 Kinetic Model; 3.3 Prediction of Pharmacokinetics During Therapy; 3.4 Absorbed Dose Calculations; 3.5 Treatment Planning; 3.6 Treatment and Quality Control Measurements; 3.7 Conclusion; 4 Dosimetry for Ibritumomab Tiuxetan; 5 Treatment Planning for [90Y]Ibritumomab Tiuxetan; 6 Conclusion and Outlook; References.
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5 Yttrium-90 (90Y)6 Indium-111 (111In); 7 Preclinical Investigation of 90Y-/111In-Ibritumomab Tiuxetan; 7.1 In Vitro Studies; 7.2 Ex Vivo/In Vivo Studies; 8 Imaging and Therapy Protocol; 8.1 Preparation of 90Y-Ibritumomab Tiuxetan; 8.2 Schedule of 90Y-Ibritumomab Tiuxetan Therapy; 9 Perspectives and Conclusion; References; Resistance and Heterogeneity of Intratumoral Antibody Distribution; 1 Introduction; 2 SPECT/CT and PET/CT System; 3 Statistical Approach Taken to Characterize Lesion's Uptake; 4 Resistance and Heterogeneity of Intratumoral Antibody Distribution.
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SUMMARY OR ABSTRACT
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This volume, in discussing resistance to ibritumomab, will focus on the mechanism, hematological aspects, radiological and nuclear medicine aspects, and medical physics that deal with radiation dosimetry, and will outline future prospects for overcoming resistance and enhancing efficacy of ibritumomab.