Intro; Contents; Contributors; Chapter 1: Osteoporosis; Case Presentation and Discussion; Introduction; Diagnosis; BMD Measurement; Fracture Risk Assessment; Evaluation; Treatment; Osteoporosis Treatment Gap; New Concepts in Osteoporosis Care; Summary; References; Chapter 2: Primary Hyperparathyroidism; Case; Introduction; Clinical Manifestations; Skeletal Manifestations; Renal Manifestations; Neuropsychiatric Manifestations; Gastrointestinal Manifestations; Cardiovascular Manifestations; Clinical Evaluation and Diagnosis; Etiologies of Primary Hyperparathyroidism
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Causes of OsteomalaciaVitamin D and Calcium Deficiency; Hypophosphatemia; Impaired Mineralization; Hypophosphatasia; Abnormal Collagen Matrix; Epidemiology; Presentation; Physical Exam; Labs; Histology; Imaging; Treatment; Vitamin D and Calcium Deficiency; Vitamin D-Dependent Rickets Type I; Vitamin D-Resistant Rickets Type II; Phosphate Disorders; References; Chapter 5: Hypoparathyroidism; Case Presentation; Introduction; Diagnosis and Etiology; Destruction or Removal of Parathyroid Glands; Genetic Disorders; Autoimmune Hypoparathyroidism; Magnesium Deficiency or Excess
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Clinical Management of HyperparathyroidismConclusion; References; Chapter 3: Non-PTH-Mediated Hypercalcemia; Case Presentation; Introduction; Hypercalcemia of Malignancy; Chronic Granulomatous Disorders; Endocrinopathies; Medications; Milk-Alkali Syndrome (MAS); Vitamin D Intoxication (VDI); Vitamin A Excess; Thiazide Diuretics; Lithium; Teriparatide and Abaloparatide; Theophylline; Estrogens and Antiestrogens; Aluminum Intoxication; Total Parenteral Nutrition (TPN); Other Diseases; Conclusion; Case Management; References; Chapter 4: Osteomalacia and Rickets; Case; Introduction
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Differential Diagnosis of HypophosphatemiaEpidemiology of Hypophosphatemic Rickets; Clinical Presentation of Genetically Inherited Renal Tubular Phosphate-Wasting Disorders; X-Linked Hypophosphatemic (XLH) Rickets; Autosomal-Dominant Hypophosphatemic Rickets (ADHR); Hereditary Hypophosphatemic Rickets with Hypercalciuria (HHRH); Autosomal Recessive Hypophosphatemic Rickets Type 1 (ARHR1); Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2); Other Rare Causes of Hypophosphatemic Rickets; Tumor-Induced Osteomalacia; Treatment; Summary and Conclusions; References
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Treatment of Acute HypocalcemiaTreatment of Chronic Hypocalcemia; Calcium Supplements; Vitamin D and Its Metabolites; Recombinant PTH; Clinical Course; Quality of Life; Effect on Bone; Fracture Risk; PTH (1-34); PTH (1-84); Conclusion; References; Chapter 6: Pseudohypoparathyroidism; Case Description; Introduction; Epidemiology; Clinical Presentation; Differential Diagnosis; Molecular Causes of Pseudohypoparathyroidism; Treatment; Summary and Conclusions; References; Chapter 7: Phosphorus Disorders: Hypophosphatemic Rickets; Case Description; Introduction
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SUMMARY OR ABSTRACT
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This concise, case-based text discusses the current state of the art for the diagnosis and management of metabolic bones diseases. Each chapter opens with a unique case presentation and utilizes a consistent format that includes relevant anatomy, physiology, and pathophysiology as well as examination, treatment approaches and clinical outcomes. Topics covered include osteoporosis, rickets and osteomalacia, hypoparathyroidism and pseudohypoparathyroidism, osteogenesis imperfecta, Paget's disease of bone, calcium and phosphorous disorders, hypophosphatasia, sclerotic bone disorders, fibrous and osteochondroplasia, and other malignancies of bone. Written and edited by experts in the field, Metabolic Bone Diseases is a valuable resource for practicing endocrinologists, rheumatologists and orthopedic surgeons, residents and fellows.