Intro; Acknowledgments; Contents; Abbreviations; List of Figures; Chapter 1: Introduction; The Perspectives of the Study; A Crowded Field: Theorizing Stem Cells; Science as Material Relations; The Issue of "Craft" in STS; Science as Craftwork; References; Part I: Clinical Translation; Chapter 2: Human Cells to the Market; Bioindustrialization; Biological Medicines and the European Union; Anticipatory Governance of Bioindustrialization; Evidence Labor; Conclusion; References; Chapter 3: Between Craft and Standardized Production; Translational Research: A View from the Laboratory
Text of Note
Automation "Up to a Point"Conclusions; References; Part III: Tissue Donation; Chapter 6: Patients and the Material Origins of Knowledge; Clinical Labor and the Craft of Biomedicine; Becoming a Donor; Donor Accounts of Instrumentality and Care; Informed Consent as the Mediator of Experimentation; Researchers and Respected Cell Material; Conclusion; References; Chapter 7: Scientific Craftwork in the Age of Bioindustrialization; Challenges of Clinical Translation; Idiosyncratic Laboratory Labor; Patients, Scientists, and Cell Lines; The Ethnographer and Stakemaking; References; Index
Text of Note
Centralized Banking of iPS Cell LinesChallenges of Biobanking: To Deposit or Withhold?; Conclusion; References; Part II: Experimentation; Chapter 4: Making iPS Cells in the Laboratory; Scientific Craftwork and the Research Laboratory; Biological Dogma Reconfigured; Patient-Specific Starting Material; Reprogramming Cells; IPS Cells in Culture; Conclusion; References; Chapter 5: Instrumentality and Care in Experimental Research; Joining Repellent Concepts: Instrumentality and Care; Learning Through Experience; The Routine of Laboratory Labor; Affective Engagement as a Skill
0
8
8
SUMMARY OR ABSTRACT
Text of Note
This book explores the new ways in which biology is becoming technology. The revolutionary iPS cell technology has made it possible to turn human skin and blood cells into pluripotent stem cells, thus providing an unprecedented opportunity to study the pathophysiology of diseases, understand human developmental biology, and generate new therapies. Drawing from a rich ethnographic study, Meskus traces the making of the iPS cell technology through the perspectives of clinical translation, laboratory experimentation, and tissue donation by voluntary patients. Discussing non-human agency, the embodied and affective basis of knowledge production, and the material politics of science, the book develops the idea of an instrumentality-care continuum as a fundamental dynamic of biomedical craft. This continuum, Meskus argues, opens up a novel perspective to the commercialization and industrial-scale appropriation of human biology, and thereby to the future of ethical biomedical research.