عنوان

A novel application of cu-pd dual catalyst system for the cross-coupling of styryltrifluoroborates and amides

Number

TL49008

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

A novel application of cu-pd dual catalyst system for the cross-coupling of styryltrifluoroborates and amides

General Material Designation

[Thesis]

First Statement of Responsibility

Mohammed Shahidul Islam

Subsequent Statement of Responsibility

Al-Masum, Mohammad

Name of Publisher, Distributor, etc.

Tennessee State University

Date of Publication, Distribution, etc.

2016

Specific Material Designation and Extent of Item

104

Text of Note

Committee members: Karim, Mohammad R.; Okoro, Cosmas; Wang, Xiaofei

Text of Note

Place of publication: United States, Ann Arbor; ISBN=978-1-369-13622-7

Dissertation or thesis details and type of degree

M.S.

Discipline of degree

Chemistry

Body granting the degree

Tennessee State University

Text preceding or following the note

2016

Text of Note

One of the most important transformations in organic synthesis is amidation reaction because of its importance as biomolecules and synthetic products. The amide bond is unique in nature. It stores amino acids to form peptides and proteins. Many nitrogen based functionality can be created into organic systems by forming new C-N bonded organic molecules. The direct amidation reaction by cross-coupling chemistry is a challenge. A Very few works have been reported for this transformation. One of the pioneering ones is reported by Buchwald group where they use palladium catalyzed coupling reaction involving aryl chlorides and acetyl amides. We are interested to see the application of potassium styryltrifluoroborates in cross-coupling with amides, which is yet to be explored. Styryltrifluoroborates and their use in enamides formation by cross-coupling with amides are largely unknown. In this work, a unique, interesting reaction procedure has been developed by using PdCl₂(d ^tbpf)-CuI dual catalyst system for cross-coupling chemistry to form new C-N bonded enamides. It is also a mild, less time consuming and green system employing microwave irradiation. ¹H NMR, ¹³C NMR, ¹¹B NMR and ¹⁹F NMR spectra have been analyzed to confirm the synthesized compounds.

Organic chemistry

Subject Term

Pure sciences;Amidation;Cross-coupling;Dual catalyst;Microwaves

Yazici Cörüt, Gözde

Al-Masum, Mohammad

Subdivision

Chemistry

Tennessee State University

Call Number

1839332095; 10158614

Electronic name

p

[Thesis]

276903

a

Y