Physiology of somatostatin / Marek Pawlikowski --; Somatostatin receptors: distribution in normal tissues and transduction mechanisms / Gabriela Melen-Mucha and Slawomir Mucha --; Somatostatin analogs: lessons in functional complexity and receptor interactions / Michael D. Culler --; Somatostatin receptors in human tumors: in vitro studies / Marek Pawlikowski --; The treatment of acromegaly with somatostatin analogs / Nuria Sucunza, Jose Barahona, and Susan M. Webb --; The treatment of neuroendocrine tumors (NET) with somatostatin analogs / Beata Kos-Kudla --; Radiolabeled somatostatin analogs in the diagnosis and therapy of neuroendocrine tumors / Leszek Krelicki, Jolanta Kunikowska, and Marianna I. Bak --; Somatostatin analogs-new perspectives / Gabriela Melen-Mucha and Marek Pawlikowski.
SUMMARY OR ABSTRACT
Text of Note
Somatostatin is a peptide isolated originally from the hypothalamus and considered as an inhibitor of growth hormone secretion. However, further studies have shown that the peptide was ubiquitously distributed and exerts a large spectrum of physiological effects, mostly of an inhibitory nature. The very short half-life of the native peptide limits its therapeutic application. To overcome this limitation the long-lasting modified molecules (analogs) of somatostatin were synthesized. The present book provides comprehensive data on the application of somatostatin analogs in diagnostics and treatm.