عنوان
پدید آورنده
موضوع
رده
QP624.75.D77 E358 1998
QP624
.
75
.
D77
E358
1998
کتابخانه
محل استقرار
INTERNATIONAL STANDARD BOOK NUMBER
(Number (ISBN
3527612165
(Number (ISBN
3527612173
(Number (ISBN
9783527612161
(Number (ISBN
9783527612178
NATIONAL BIBLIOGRAPHY NUMBER
Number
b563648
TITLE AND STATEMENT OF RESPONSIBILITY
Title Proper
Structure-based ligand design
General Material Designation
[Book]
First Statement of Responsibility
edited by Klaus Gubernator, Hans-Joachim Böhm.
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Weinheim ; New York
Name of Publisher, Distributor, etc.
Wiley-VCH
Date of Publication, Distribution, etc.
©1998.
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
(xiv, 153 pages) : illustrations
SERIES
Series Title
Methods and principles in medicinal chemistry, v. 6.
CONTENTS NOTE
Text of Note
Rational Design of Bioactive Molecules Examples of Active Areas of Structure-Based Design From Renin to HIV-1 Protease Zinc Endoproteases: A Structural Superfamily Structure-Based Design of Potent Beta-Lactamase Inhibitors Inhibition of Sialidase Rational Design of Inhibitors of HIV-1 Reverse Transcriptase New Computational Approaches to Predict Protein-Ligand Interactions The Future of Structure-Based Design: A Worthy Precept?
SUMMARY OR ABSTRACT
Text of Note
Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical research. Much has been learned, however, since the first attempts to discover drugs on the basis of available biochemical and structural data. Nowadays, structure-based ligand design is an established method for creating drugs with new structural features, for modifying binding activities and pharmaco.
TOPICAL NAME USED AS SUBJECT
Ligand binding (Biochemistry)
Pharmaceutical chemistry.
QSAR (Biochemistry)
LIBRARY OF CONGRESS CLASSIFICATION
Class number
QP624
.
75
.
D77
Book number
E358
1998
PERSONAL NAME - PRIMARY RESPONSIBILITY
edited by Klaus Gubernator, Hans-Joachim Böhm.
PERSONAL NAME - ALTERNATIVE RESPONSIBILITY
Hans-Joachim Böhm
Klaus Gubernator
ELECTRONIC LOCATION AND ACCESS
Electronic name
مطالعه متن کتاب [Book]
Y
