MECHANISMS OF CANCER METASTASIS; DEVELOPMENTS IN ONCOLOGY; Editor's page ; Copyright; CONTENTS; CONTRIBUTORS ; PREFACE; CHAPTER 1. THE CANCER PROBLEM TODAY; CHAPTER 2. PRESENT STATUS AND FUTURE PROSPECTS FOR TREATMEIT OF METASTATIC CANCER ; CHAPTER 3. A CRITICAL OVERVIEW OF THE METASTATIC PROCESS; CHAPTER 4. EXPERIMENTAL MODELS FOR STUDYING THE PATHOGENESIS AND THERAPY OF METASTATIC DISEASE ; CHAPTER 5. PROBLEMS POSED FOR CANCER TREATMENT BY TUMOR CELL HETEROGENEITY; CHAPTER 6. MULTIDRUG RESISTANCE AND METASTASIS ; CHAPTER 7. POLYAMINE BIOSYNTHESIS: A TARGET FOR ANTIMETASTATIC THERAPY. CHAPTER 8. CHEMICAL MECHANISMS OF MODULATION OF TUMOR GROWTH AND METASTASIS BY PROSTAGLANDINS CHAPTER 9. PLATELET-TUMOR CELL INTERACTIONS AS A TARGET FOR ANTIMETASTATIC THERAPY ; CHAPTER 10. MECHANISMS OF INHIBITION OF CANCER DISSEMINATION BY WARFARIN ; CHAPTER 11. CANCER CELL PROCOAGULANTS AND THEIR POSSIBLE ROLE IN METASTASIS; CHAPTER 12. ROLE OF GROWTH STIMULATORY FACTORS IN DETERMINING THE SITES OF METASTASIS; CHAPTER 13. INTERLEUKINS, LYMPHOKINES AND LYMPHOID NEOPLASIA; CHAPTER 14. THE USE OF ACTIVATED MACROPHAGES FOR THE DESTRUCTION OF HETEROGENOUS METASTASIS. CHAPTER 15. BIOLOGICAL RESPONSE MODIFIERS AS ACTIVATORS OF NATURAL KILLER CELLS: POTENTIAL ROLE IN TREATMENT OF METASTASIS CHAPTER 16. BREAST CANCER DIAGNOSIS WITH HUMAN MAMMARY EPITHELIAL ANTIGENS AND THE PROSPECTIVE USE OF ANTIBODIES AGAINST THEM IN THERAPY ; CHAPTER 17. CHEMOTAXIS IN TUMOR CELLS: POSSIBLE MECHANISMS AND THEIR IMPLICATIONS FOR THERAPY ; CHAPTER 18. INVASION OF VASCULAR ENDOTHELIUM AND ORGAN TISSUE IN VITRO BY B16 MELANOMA VARIANTS; CHAPTER 19. DOMAINS OF LAMININ AND BASEMENT MEMBRANE COLLAGEN WHICH PLAY A ROLE IN METASTASES. CHAPTER 20. INTERACTION OF MALIGNANT CELLS WITH SUBSTRATA: ADHESION, DEGRADATION AND MIGRATIONCHAPTER 21. PROTEOLYTIC ENZYMES IN TUMOR INVASION AND DEGRADATION OF HOST EXTRACELLULAR MATRICES ; CHAPTER 22. CATHEPSIN B-LIKE CYSTEINE PROTEINASES AND METASTASIS; CHAPTER 23. APPLICATIONS FOR ANTIMETASTATIC THERAPIES ; INDEX.